Profluent

@ProfluentBio

Grounded in nature, authored by AI

Emeryville, CA

profluent.bio

Joined September 2022

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Profluent
@ProfluentBio
Nov 19, 2025
Today we’re announcing $106M in new funding led by Altimeter Capital and Bezos Expeditions. This brings our total to $150M to scale our frontier AI models which make biology programmable. Our frontier models have generated functional proteins (Nature Biotech, 2023), created the
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Profluent
@ProfluentBio
Aug 12
Stephen Nayfach, our Head of Bioinformatics and Platform R&D, is at @CSHL this week for the Genome Engineering: CRISPR Frontiers event. Find him and say hi if you're there! 👋 He's giving a talk on using our AI models to design CRISPR-Cas9 variants for base editing ("Programming
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Profluent
@ProfluentBio
Jul 30
The Profluent team is heading to Summer RosettaCon next week! Find @jeffruffolo, @richardwshuai, @ShiakiMinami, and Alex Hoffnagle and say hi 👋 You can hear Richard talk about E1, our encoder model, on Thur at 1:30pm (“E1: Retrieval-Augmented Protein Encoders for Fitness and
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Profluent
@ProfluentBio
Jul 9
A suite of AI-designed base editors, all from one scaffold. The only piece unique to each patient is the guide RNA. That's the shift AI unlocks: rare disease moves from 'one drug at a time' to a platform, built to bring cost down and reach more patients. More on our work with
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Profluent
@ProfluentBio
Jul 9
The bottleneck in rare disease is design: too many mutations, one editor at a time. AI unlocks that. Proud to be building GemmaBio's platform with them under @ARPA_H 's THRIVE program. We're bringing our frontier AI models and base editors to the work to design modular gene
ARPA-H
@ARPA_H
Jul 9
95% of rare diseases have no approved treatment. When your child is getting sicker, waiting isn’t an option. ARPA-H is investing $160 million through THRIVE to accelerate personalized genetic cures for the kids who need them most. A rare diagnosis should never mean no hope for