Articles
Innovative Tools Driving Progress in Neuroscience Research
Neuroscience is a multidisciplinary field dedicated to studying the nervous system, including the brain, spinal cord, and peripheral nerves. Pharmaceutical companies are developing drugs targeting neurological conditions characterized by cognitive and motor dysfunction due to neuronal or nerve damage, such as Alzheimer’s and Parkinson’s diseases. Read More
Precision Oncology Meets Potency: The Promise of Antibody-Drug Conjugates
Antibody–Drug Conjugates (ADCs) are targeted oncology therapeutics that combine a monoclonal antibody with a highly potent cytotoxic small molecule. This design enables selective delivery of the drug to tumor cells while minimizing off-target effects. Read More
Cytotoxicity assays for the evaluation of therapeutic antibodies and bispecific immune engagers
Therapeutic antibodies are widely used to treat cancer, immune-related disorders and inflammatory conditions, or to neutralize viral infections. These antibodies can function as agonists or antagonists, block ligand-receptor interactions, or bind viral proteins to prevent infection, among other mechanisms. Read More
Bridging ELISA Kits for Bispecific Immune Engagers
Antibodies represent a cornerstone of modern therapeutics, demonstrating remarkable efficacy in oncology and immunology. Bispecific Immune Engager antibodies are designed to bind simultaneously to a therapeutic target on cells of interest such as cancer cells and to a specific cell surface molecule on immune cells such as T cells or NK (natural killer) cells. Read More
Myostatin Cell Lines: Insights into Muscle Growth and Differentiation
Myostatin (MSTN), also known as GDF8 (growth differentiation factor 8), a member of the transforming growth factor-beta (TGF-β) superfamily, plays a crucial role in the regulation of skeletal muscle growth. It acts as a negative regulator by inhibiting myoblast proliferation and differentiation. Read More
Advancing Immune Disease Treatment with Cutting-Edge Drug Discovery Tools
Therapeutic antibodies targeting interleukin-induced signaling pathways are transforming the treatment of immune-related diseases. Engineered interleukin receptor-expressing cells enable high-throughput screening and precise assessment of drug candidates by quantifying cytokine response through STAT-dependent luciferase reporter activity. Read More
Overcoming Challenges in the Culture of Human Immune Cells
As living systems, cells require high-quality culture environments to survive and maintain their biological characteristics. Primary immune cells are particularly sensitive, with their performance critically dependent on media composition. Culture media provide essential nutrients like amino acids, carbohydrates, vitamins, growth factors, and hormones that support cellular function. Read More
Propel your research forward with iPS cells
Induced pluripotent stem cells (iPSC), pioneered by Nobel Prize winner Shinya Yamanaka, are generated by converting mature human somatic cells via expression of four critical transcription factors known as Yamanaka factors: Myc, Sox2, Klf4, and Oct3/4. iPSCs are a valuable tool for research as they can differentiate into various cell types, including those of different tissues and organs. Read More
Lentiviral Tools for Cell Engineering
Lentiviruses (LVs) are RNA-based enveloped viruses that enter cells by binding to a particular cell surface protein, followed by membrane fusion, which pours into the cytoplasm the viral RNA containing its genetic information. This single-stranded viral RNA is turned into DNA by reverse transcription. The viral DNA enters the nucleus and is integrated into the host cell genome by a viral integrase. Read More
Illuminate Metabolic Pathways with Luciferase Reporter Cells
The market for drugs treating metabolic dysfunction-associated steatohepatitis (MASH), obesity, diabetes, and other metabolic disorders is expected to grow dramatically, fueled by emerging therapies targeting the nuclear receptor thyroid hormone receptor beta (TRβ), or targeting G-protein Coupled Receptors (GPCRs) such as Glucagon-like Peptide-1 Receptor (GLP-1R). Read More
Unleash the therapeutic potential of NK cells
NK cells are critical effectors of innate immunity against cancer, pathogen-infected cells, and antibody-targeted cells. Their significance in adoptive cell therapy is underscored by the current surge of research into Chimeric Antigen Receptor (CAR) NK cells and multi-specific NK cell engagers, particularly for cancer therapy. Read More
Biochemical and cell-based assays to interrogate ADP-ribosylation
The reversible addition of ADP-ribose units to proteins is a vital post-translational modification involved in cellular processes such as DNA repair, chromatin remodeling, and control of gene expression. It happens in proteins linked to the DNA Damage Response (DDR). Read More
Sortase-Mediated Conjugation: A Precise Tool for Protein & Antibody Engineering
Sortase-mediated conjugation is a powerful technique for the precise engineering of enzymatic tools or therapeutic biologics. It enables site-specific attachment of antibodies and proteins to various molecules and materials, including fluorescent labels for imaging and sorting, pharmaceutical compounds, nanoparticles, and even cells for drug delivery. Read More
