Using a mosaic nanoparticle platform, researchers interrogate how antigen avidity shapes the durability of responses to HIV vaccines in mice and show that high valency elicits more robust B cell and germinal center responses. @UTMB_Pathology scim.ag/4gtOAly
Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine.
- By analyzing more than 800,000 single-cell profiles in tissues and blood, a team assembles a massive biomolecular compendium of lupus nephritis that maps out its impact on cell populations and could inform future therapeutics. @soumya_boston @BrighamWomens scim.ag/4wDB7MI
- By parsing the DNA #fragmentome, a team identifies cell-free DNA signatures that can give early warning during the first trimester of pregnancy complications in women with risk factors such as twinning and autoimmune disease. @CHG_CME @KateEStanley1 scim.ag/3UavEj4
- The new issue of #ScienceTranslationalMedicine is out now! The DNA fragmentome can give early warning about pregnancy complications in high-risk patients, a compendium of lupus nephritis reveals how the condition skews cells and tissues, and more. scim.ag/4x6M8HL
- Combining mutant #p53 reactivation via arsenic trioxide with the standard therapy decitabine kills acute myeloid leukemia and MDS cells and shows promise in a small pilot trial in patients carrying rescuable p53 mutations. @sjtu1896 scim.ag/4cnWLgN

