Roth_Lab

@Roth_Lab

Genetic Technologies and New Gene Design for Curative Therapies @Stanford - @parkerici - @arcinstitute

Stanford, CA

Roth_Lab
@Roth_Lab
Aug 19
Transcription Factors are central to cellular identity and function. The human genome currently contains ~1600 of them. But could there be productive human transcription factors that have not evolved? Out today in Cell, a tremendously talented graduate student Oliver Takacsi-Nagy
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Roth_Lab
@Roth_Lab
Apr 10
The size of new DNA sequences that can be integrated into the human genome is a foundational constraint for engineering and enhancing human cells. In a new collaborative study, we’ve now almost doubled the maximum size of DNA sequences that can be efficiently inserted into
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Roth_Lab
@Roth_Lab
Mar 30
Genome wide perturb seq creates powerful perturbations x transcripts datasets. This unveils new biology - but also reveals new off-target effects. New work from @AustinMHartman, a massively talented PhD student in our lab, systematically identifies seed driven off-target effects
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Roth_Lab
@Roth_Lab
Nov 21, 2025
Excited to present the first major work after starting our lab at Stanford and the Arc this year: CRISPR-All, a unified genetic perturbation language for programming any major type of genetic perturbation simultaneously, in any combination, at genome scale, in human cells.
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