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Eterna
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@eternagame

Eterna

@eternagame
Eterna is a videogame where you can invent medicine. You solve RNA design puzzles, and your solutions get synthesized and tested by biochemistry & robotics!
Stanford, CA
eternagame.org
Joined October 2010
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  • @eternagame
    Eterna
    @eternagame
    Aug 27
    We made the cover of Science! Congratulations to all the players and researchers who worked so hard on the OpenKnot project the last two years.
    @ScienceMagazine
    Science Magazine
    @ScienceMagazine
    Aug 27
    On the citizen science platform Eterna, #AI methods matched expert human players at inventing sequences that fold into an RNA pseudoknot, a structure in which loops pair with distant parts of the same molecule. This opens a route to automatically designing RNA therapeutics,
    Each diagram is a designed RNA pseudoknot, a structure in which loops pair with distant parts of the same molecule. On the citizen science platform Eterna, artificial intelligence methods matched expert human players at inventing sequences that fold into these shapes, opening a route to automatically designing RNA therapeutics, sensors, and catalysts from scratch.

Image: J. Townley et al., Science 393 , 931 (2026); Adapted by N. Jessup/Science
  • @eternagame
    Eterna
    @eternagame
    Aug 7
    Our Replicase pilot results found that the catalytic activity and copyability of the 71-89 polymerase ribozyme can be improved! We have launched a new puzzle for finding a version that excels at both properties simultaneously. Comp methods are encouraged to submit designs!
    Puzzle interface displaying both the secondary and tertiary structure of the ribozyme
    2
  • @eternagame
    Eterna
    @eternagame
    Aug 6
    Major props @DidiKieran @jgkoob @lemerleau @IIMCB_Poland @FrankRHutter @AF_Panescu @chaitjo @rishabh16_ for generating 600,000 sequences to fold into 1000 synthetic pseudoknots! The wet lab results will help these researchers improve their computational methods for RNA design.
    @eternagame
    Eterna
    @eternagame
    Jul 23
    OpenKnot Round 9 features secondary structures designed by players to create compact, pseudoknotted RNA using 240 bases. GenAI teams also will test whether their methods perform as well as the expert players at a longer length. Check out the puzzle at: eternagame.org/labs/14343053
    Screenshot of Eterna puzzle interface
  • @eternagame
    Eterna
    @eternagame
    Jul 23
    OpenKnot Round 9 features secondary structures designed by players to create compact, pseudoknotted RNA using 240 bases. GenAI teams also will test whether their methods perform as well as the expert players at a longer length. Check out the puzzle at: eternagame.org/labs/14343053
    Screenshot of Eterna puzzle interface
  • @eternagame
    Eterna
    @eternagame
    Jul 17
    Eternacon 12 will be Sunday, July 26, 9am to 2pm PT featuring talks on player pseudoknot design techniques, the Montparnasse algorithm solving the Eterna100, an RNA scaffold for cryo-EM, and results for our pilot Replicase puzzle. Free to register at eternagame.org/eternacon/2026
    Logo for eternacon 12
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