Das Lab

@RDasLab

Our lab seeks an agile and predictive understanding of how RNAs structurally code for information processing and replication in living systems.

Stanford, CA

daslab.stanford.edu

Replies Reposts Media

Das Lab
@RDasLab
Aug 27
Our paper with @eternagame, 5 AI teams, and cryo-EM collabs on de novo design of #RNA pseudoknots with #deeplearning is out in @ScienceMagazine ! Comes with a provocative commentary on RNA structure prediction by @TonyMustoe lab! doi.org/10.1126/scienc… doi.org/10.1126/scienc…
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Eterna
@eternagame
Aug 27
We made the cover of Science! Congratulations to all the players and researchers who worked so hard on the OpenKnot project the last two years.
Das Lab
@RDasLab
Aug 17
Finally, 3D #cryoEM structure of a nucleotide polymerizing #RNA that copies #RNA to #RNA: tC19z, evolved at LMB MRC 15 y ago! biorxiv.org/content/10.648… @Szokoli_Deni Jason Hingey, Dan Haack, Vivian Wu @nickspellmon @navtejtoor @HHMIJanelia
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Das Lab
@RDasLab
Aug 8
We and @eternagame are joining the quest to find a molecule that can sustainably replicate itself. Pilot results on first 1000 designs are posted, next up will be million-design-scale expts. Come design at eternagame.org/labs/14660266 by Aug 31, 2026! #RNAworld
Eterna
@eternagame
Aug 7
Our Replicase pilot results found that the catalytic activity and copyability of the 71-89 polymerase ribozyme can be improved! We have launched a new puzzle for finding a version that excels at both properties simultaneously. Comp methods are encouraged to submit designs!
Das Lab
@RDasLab
Aug 6
#RNA computational design groups around the world delivered! Congrats as well to @eternagame players who contributed the 240-nt pseudoknot targets -- and baseline RNA sequences for #AI eval. Experiments are underway at @StanfordBiochem @HHMI Janelia Research Campus.
Eterna
@eternagame
Aug 6
Major props @DidiKieran @jgkoob @lemerleau @IIMCB_Poland @FrankRHutter @AF_Panescu @chaitjo @rishabh16_ for generating 600,000 sequences to fold into 1000 synthetic pseudoknots! The wet lab results will help these researchers improve their computational methods for RNA design.
Das Lab
@RDasLab
Jul 24
RNA flexible? Maybe we can model that. First blind test of RNA 3D *ensemble* prediction — ligand-free SAMURI ribozyme (displayed on a group II intron scaffold) -- #MD and #deeplearning methods welcome, deadline Aug 22, 2026: predictioncenter.org/casp17/target.…