conuly: (Default)
[personal profile] conuly
And very heavy on the dudes. I'm not sure if women don't go into this sort of thing, or if they're just too classy when they do it, and thus don't get onto the playlist. Though I guess it would be strange for lesbians to sing an ode to Jingle Bell COCK. (Emphasis all theirs, and totally unnecessary. We know where the song was going.)


Anyway, in honor of this, I'm posting three belated Christmas videos. The last is Boynton and totally SFW.





This one won't let me embed it.

A Newtonmass* walk

Dec. 25th, 2025 07:34 pm
magid: (Default)
[personal profile] magid
I find it too easy to stay home when I don’t have particular reasons to leave the house, but I’m trying to resist this. It took until late afternoon for me to get out, though. I headed out Brattle St.; it’s where I defaulted to walking during the early days of the pandemic, because it’s very pretty with all the historic houses, plus the trees and other greenery make it feel more spacious. This afternoon felt similar because there was so little traffic, likely not only because of the holiday but also due to the cold winds blowing.

The houses were pretty in their Christmas decorations, which tended towards little white fairy lights, swags of fresh greenery along fences, and various bows and wreaths, very understated compared to some. I was surprised to note three houses for sale on Brattle St. just between Longfellow House and Fayerweather St. That seems like a lot of turnover at once.

I found what I thought might be a foreign coin (the color was too brassy to be US currency), but turned out to be a vacuum token. I couldn’t figure it out until I got home and thought to check the obverse: apparently carwashes can have vacuum tokens.

I visited one of the biggest trees I know of in Cambridge, at 12 Reservoir St. It’s gorgeous (but not on the city’s map of trees***, because it’s on private land, not public).

I saw turkeys twice: the first was a pair on Sparks St., while the second was a group of 15 on Craigie St. It seemed to me that they were all hens, no males at all. Happily, they went about their own business without interacting with the humans nearby.

I went down Berkeley St., which gave me the chance to visit one of my favorite historical markers, at the house where the future Thai Princess Mother Sangwan Talapat lived from September 1919 to April 1920. It’s fifth on this list of the Massachusetts Trail of Thai Royalty.

And then home in the gloaming, thinking about my options for lunch.

* I know it should be Newtonmas**, but given his achievements, ‘mass’ feels more appropriate. (It would’ve been even more appropriate had I managed to walk to Newton, though.)

** Clara Barton was also born on December 25, but no one uses Bartonmas/Bartonmass (she grew up in MA, even, having been born in North Oxford). (More about her accomplishments from Wikipedia.)

*** This is from the city’s open data sets, which includes a whole lot of information, even including lists and maintenance of public art and sidewalk poetry.

weight and sleep and health

Dec. 24th, 2025 09:26 am
hudebnik: (Default)
[personal profile] hudebnik
159.8 lbs.
breakfast: grapefruit, yogurt, cereal, soy milk, dried cranberries
mid-morning: protein bar
lunch: fish, tapenade, quinoa, dessert bites
mid-afternoon: trail mix
dinner: hamburger, French fries
snacks: cookies
dessert: hot chocolate

In bed 12:30ish, with D. Up 8:45.
mdlbear: Wild turkey hen close-up (turkey)
[personal profile] mdlbear

Today is Isaac Newton's Birthday, so I'd like to start by wishing you all a very Heavy Newtonmas. I am thankful for...

  • Friction, and in particular socks with grippy bottoms for wearing around the house.
  • Gravity, without which those socks wouldn't work. (Neither would a lot of other things, of course. I'm also looking for a little levity, and not finding nearly enough.)
  • The reason for the season -- axial tilt. Also, having just about the right amount of it. (Uranus has way too much!)
  • Calculus -- integral, differential, and lambda.
  • Number systems in which infinitesimals are, um..., well-defined. I guess you can't say "real", can you?
  • Choice.
  • Having slightly less mass than I did last year. (Very slightly, but I'll take what I can get.) Good drugs.

Coulda, Shoulda, but Didn't

Dec. 24th, 2025 09:31 pm
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[personal profile] fauxklore
I am not doing brilliantly at getting things done. I still need to finish holiday cards, for example. And, in particular, I need to find where I put the stamps I am sure I have.

I also need to finish finalizing some travel plans. There are tickets to various events that I need to buy, too.

And I am nearly out of clean clothes.

I could, theoretically, be getting some of this done tonight. But, I think I am going to prioritize the book I’m in the middle of.
siderea: (Default)
[personal profile] siderea
2025 Dec 24: ScienceDaily [press release?]: "Scientists reverse Alzheimer’s in mice and restore memory":
By examining both human Alzheimer's brain tissue and multiple preclinical mouse models, the team identified a key biological failure at the center of the disease. They found that the brain's inability to maintain normal levels of a critical cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. Importantly, maintaining proper NAD+ balance was shown to not only prevent the disease but also reverse it in experimental models.
WARNING WARNING WARNING: Yes, there are OTC supplements for tinkering with your NAD+, but they are apparently/allegedly CARCINOGENIC (cause CANCER) at typical doses. DO NOT run out and do something stupid. Tinkering with your whole-body cellular metabolism has some gnarly failure modes. From this article:
Why This Approach Differs From Supplements

Dr. Pieper cautioned against confusing this strategy with over the counter NAD+-precursors. He noted that such supplements have been shown in animal studies to raise NAD+ to dangerously high levels that promote cancer. The method used in this research relies instead on P7C3-A20, a pharmacologic agent that helps cells maintain healthy NAD+ balance during extreme stress, without pushing levels beyond their normal range.
Continuing from the article:
NAD+ levels naturally decline throughout the body, including the brain, as people age. When NAD+ drops too low, cells lose the ability to carry out essential processes needed for normal function and survival. The researchers discovered that this decline is far more severe in the brains of people with Alzheimer's. The same pattern was seen in mouse models of the disease.

[...]

Amyloid and tau abnormalities are among the earliest and most significant features of Alzheimer's. In both mouse models, these mutations led to widespread brain damage that closely mirrors the human disease. This included breakdown of the blood-brain barrier, damage to nerve fibers, chronic inflammation, reduced formation of new neurons in the hippocampus, weakened communication between brain cells, and extensive oxidative damage. The mice also developed severe memory and cognitive problems similar to those seen in people with Alzheimer's.

[...]

This approach built on the group's earlier work published in Proceeding of the National Academy of Sciences USA, which showed that restoring NAD+ balance led to both structural and functional recovery after severe, long-lasting traumatic brain injury. In the current study, the researchers used a well-characterized pharmacologic compound called P7C3-A20, developed in the Pieper laboratory, to restore NAD+ balance.

The results were striking. Preserving NAD+ balance protected mice from developing Alzheimer's, but even more surprising was what happened when treatment began after the disease was already advanced. In those cases, restoring NAD+ balance allowed the brain to repair the major pathological damage caused by the genetic mutations.

Both mouse models showed complete recovery of cognitive function. This recovery was also reflected in blood tests, which showed normalized levels of phosphorylated tau 217, a recently approved clinical biomarker used to diagnose Alzheimer's in people. These findings provided strong evidence of disease reversal and highlighted a potential biomarker for future human trials.
Note, potential conflict of interest: the head of the lab, Dr Pieper, above, has a serious commercial interest in this proving out:
The technology is currently being commercialized by Glengary Brain Health, a Cleveland-based company co-founded by Dr. Pieper.
The actual research article:

2025 Dec 22: Cell Reports Medicine [peer-reviewed scientific journal]: Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain by Kalyani Chaubey et al. (+35 other authors!):
Abstract:

Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.
Full text here: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

Lesson learned

Dec. 24th, 2025 06:04 pm
magid: (Default)
[personal profile] magid
Monday I put in an order for delivery by the Wandering Que (a kosher BBQ place in NJ): they were offering dropoff at the local Chabad (0.75 miles from home), Wednesday between noon and 1p.

What actually happened… )

Books I've Read: January-April 2025

Dec. 24th, 2025 11:52 am
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[personal profile] hrj
It's going to be a bit trickier to create this post while visiting at my Dad's place since my process involves three different windows (spreadsheet of reading notes, Dreamwidth entry, and database for finished reviews) which I can normally pull up on different screens.

A Sorceress Comes to Call by T. Kingfisher -- (audio) The plot is...well, let’s call it “allusive of” rather than “based on” the fairy tale of the goose girl and her talking horse. There’s a horribly abusive mother (whose comeuppance is similar to the climax of my fairy tale The Language of Roses), a sympathetic ingenue, and a lovely second-chance romance involving an older woman (a Kingfisher specialty). Big content notice for violence and coercion. It's a very painful story, so I'm not sure that "enjoyable" is the right description, but I'm glad I read it.

Murder in an English Village by Jessica Ellicott -- (audio) I was exploring some sale books to see if I could find any interesting historic mysteries and thought this book looked interesting. It’s set between the World Wars and involves two old school chums—-one an English spinster and one an American adventuress—-who stumble into several mysteries. It’s a pleasant enough mystery, though I was unwarrantedly hoping for a touch more sapphic subtext, along the lines of Miss Buncle’s Book.

A Room of One's Own by Virginia Woolf -- (audio) Picked up from an audiobook sale, in part because I'd done an interview where the interviewee made the assumption that of course every feminist has read Woolf and I realized I hadn't. A Room of One's Own is broadly about the difficulties of being a woman writer. Pair this classic with Joanna Russ’s How To Suppress Women’s Writing and then sink into a deep depression about how little has changed since those books were written.

All the Painted Stars by Emma Denny -- (audio) A pleasant enough medieval f/f romance with competent prose, but the historic grounding is exceedingly thin and occasionally annoying. Horses aren't cars. Parchment isn't post-its. Village brewers don't work at industrial scale. It wasn’t a matter of large inaccuracies, but of a constant flow of small details that kept distracting me from the endearing main characters. This book is a follow-on from her previous one which focused on a gay male couple. The two stories are connected by family ties.

The Imposition of Unnecessary Obstacles by Malka Older -- (audio) The second in a sapphic space-mystery series. These are novellas set in a colony constructed around Jupiter after humanity fled an uninhabitable Earth. Murder mysteries get solved by a detective and academic duo who are also negotiating a revival of their romance. The books are enjoyable and have a fun time grounding the mysteries in the worldbuilding.

The Golem and the Jinni by Helene Wecker -- (audio) I finally got around to reading this highly praised book, which came out a number of years ago. The novel asks the question: can a naïve and brilliant golem who has lost her immigrant master on the voyage to America, and a metal-working Jinni newly freed from magical entrapment find their way together in early 20th century New York and foil the schemes of the sorcerer who wants to re-enslave them both? This was beautiful and heartbreaking and ultimately triumphant and I don’t know what took me so long to come back to it, given that I’ve owned a hard copy since it first came out.

Gentleman Jack by Anne Choma -- (audio) I don’t usually consume books for the lesbian history blog via audiobook -- it makes it hard to take notes! It made sense in this case because it’s more of a narrative history rather than a scholarly analysis. This is a narrative history of Anne Lister’s life between November 1831 and March 1834, the period covered by the tv series Gentleman Jack. The book was written specifically as a companion to the tv series, giving the actual details of Anne’s life during that period, which differ in various details from the tv series. (The tv series both omitted and invented significant details.) Interspersed in the narrative are extensive quotes from Anne’s diaries. The account is very readable and will give you a solid background of Anne’s life and times. It is neither a scholarly historical analysis (for that, you might try Jill Liddington) nor an extensive and contextualized survey of significant portions of the diaries (for which you want Helena Whitbread). But it hits a sweet spot for the general reader. And if you’re a fan of the tv series, it makes an interesting “compare and contrast” to understand how history gets adapted for the requirements of drama.

The Tomb of Dragons by Katherine Addison -- (audio) I think this finishes up the Cemetaries of Amalo series, set in the same universe as The Goblin Emperor. As with previous books in the series, there are a number of plot threads that braid together in the resolution. Our protagonist, a "witness for the dead" who can communicate with dead souls finds himself representing a murdered dragon. One of the other major plot threads about an escaped insurgent ties back in at the climax in a way that feels a little too convenient. And there's a surprising twist to a hinted-at romance arc that's been developing across the series.

The Suffragette Scandal by Courtney Milan -- (audio) I've read several Courtney Milan historic romances in the past, with mixed impressions. This one worked very well for me, centering around Victorian-era feminist movements and one of her favorite tropes: aristocrats who are desperately trying to escape their fate. But the reason I picked it up was for the very-much-background sapphic romance that has been slipped into the cracks of the main story.

I was originally going to do just January and February in this post, but then there were only two books I finished in March, and none in April, so it made sense to expand the official scope. (April was, of course, my last month on the job and I was a bit distracted.) Looking ahead in the spreadsheet, I may do another four-month set in the next post and then do one post each for the final four months of the year, based on numbers.

Christmas achievements

Dec. 24th, 2025 06:54 pm
shewhomust: (ayesha)
[personal profile] shewhomust
It is Christmas Eve, and this morning I submitted my tax return. That's the big one.

The milkman left five pints this morning, which will have to last us until Monday morning. We have succeeded in fitting it into the fridge.

I (we, in fact) have stripped the bed, and there is washing in the machine. I have placed an order with Ocado for just before the New Year (there's plenty of time to edit the order, but the delivery slot is reserved). [personal profile] durham_rambler went out this morning to collect his prescription and - above and beyond the call of duty - managed to snag a red cabbage (I'd been unsuccessful at both Sainsbury's and Aldi).

Yesterday we went to lunch with J: which was fun, but it's just the two of us now until D. and [personal profile] valydiarosada arrive for the New Year.

So we are ready for whatever the next few days may bring.

Season's greetings, everyone!

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