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Fifty Years
2,893 posts
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Fifty Years
@fiftyyears
Make something civilization needs. Helping great scientists and engineers become great entrepreneurs is our jam.
San Francisco, CA
substack.fiftyyears.com
Joined July 2016
85
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15.3K
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  • Pinned
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    Fifty Years
    @fiftyyears
    Oct 13, 2024
    Make something civilization needs.
    128K
  • Fifty Years reposted
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    Marius Hobbhahn
    @MariusHobbhahn
    Jun 22
    We’re hiring for two roles on the monitoring / control team that I’m very excited about: 1. AI security & control engineer: Design threat models for adversarial agents, red-team Watcher and prioritize failure modes Watcher should protect against. 2. Research Scientist
    17K
  • Fifty Years reposted
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    Nabla Bio
    @nablabio
    13h
    Today, we expand zero-shot drug design beyond binding to the design of multifunctional medicines, the intracellular proteome, and state-of-the-art atomic precision with our model, JAM-2. In a new report (below), we show: 1. The first drug-grade, fully computationally designed
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    66K
  • Fifty Years reposted
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    Seth Bannon
    Fifty Years
    @sethbannon
    11h
    The most exciting field right now is AI × bio. Nabla zero shot designed antibodies straight from from sequence that kill cancer cells at 70 picomolar, spare healthy ones over a single amino acid, and fold exactly as predicted to within an angstrom. Validated, not hype!
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    Nabla Bio
    @nablabio
    13h
    Today, we expand zero-shot drug design beyond binding to the design of multifunctional medicines, the intracellular proteome, and state-of-the-art atomic precision with our model, JAM-2. In a new report (below), we show: 1. The first drug-grade, fully computationally designed
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    00:00
    16K
  • Fifty Years reposted
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    Seth Bannon
    Fifty Years
    @sethbannon
    Jun 19
    Congratulations to my old boss. Empathy, intelligence, coolness under pressure, and goodness to the core. We need more of this. Was great jamming with him on what we're building at @fiftyyears, and how we can ensure AI creates a better future for humanity.
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    6.2K
  • Fifty Years reposted
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    Matt Loszak
    Aalo Atomics
    @MattLoszak
    Jun 1
    "You can't build nuclear quickly" Built our first 10 MW-scale reactor and facility from bare dirt in 5 months. "You can't build nuclear affordably" Only spent $70M in our company history. Includes our real reactor & facility, fuel, prototypes, factory & equipment, payroll,
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    176K
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    Fifty Years
    @fiftyyears
    May 29
    Another day another slickly produced video announcing another massive round, often for things that shouldn't exist. "Prediction markets" that are really just online casinos. AI fake-influencer startups built to deceive people. Can't we do better?
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    1.1M
  • Fifty Years reposted
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    Elicit
    @elicitorg
    May 28
    Elicit now has an MCP server. Use it inside Claude, ChatGPT, Copilot, Gemini, and any MCP-compatible tool. Agents hallucinate when they don't have access to the right evidence. With Elicit's MCP, they search 138M+ papers and cite instead of guess. Ask your agent to run a full
    docs.elicit.com
    Elicit API Reference
    Complete API reference for the Elicit research automation platform. Explore endpoints, parameters, and schemas for programmatic access to Elicit's research tools.
    1.7K
  • Fifty Years reposted
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    ✶ ela ✶
    @elamadej
    May 28
    i think i solved it. Physics PhD, sci-fi writer, AI founder, now a biotech CEO trying to save the world? @hannu must be superhero from a Marvel universe coming to help us out. listen to @ashleevance's pod with Hannu and ponder: 1. How can we be better "parents" to the world
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    Ashlee Vance
    @ashleevance
    May 27
    Good lord he's fun to listen to
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    6.2K
  • Fifty Years reposted
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    Justin Olshavsky
    @olshav
    May 28
    You should work on problems where being right actually matters
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    Seth Bannon
    Fifty Years
    @sethbannon
    May 26
    Can't we do better? First short film from @fiftyyears.
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    3.7K
  • Fifty Years reposted
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    vesper is in SF 🌁
    Meteora
    @vesper792
    May 27
    can’t we do better? @fiftyyears for storytelling that moves.
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    Seth Bannon
    Fifty Years
    00:00
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    Seth Bannon
    Fifty Years
    1.5K
  • Fifty Years reposted
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    Wojciech Zaremba
    @woj_zaremba
    May 27
    Can’t we do better? A compelling short video from @fiftyyears that gave me goosebumps about what it means to create value in the world.
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    16K
  • Fifty Years reposted
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    Bilal Zuberi // Red Glass Ventures
    @bznotes
    May 27
    This is very cool! Good stuff, @fiftyyears.
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    Seth Bannon
    Fifty Years
    @sethbannon
    May 26
    Can't we do better? First short film from @fiftyyears.
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    00:00
    5.8K

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