Yulab (@YulabJin) / X

Yulab

670 posts

Yulab

@YulabJin

breaking one CH bond per day...keeping headaches away...

Joined December 2016

Yulab
@YulabJin
Sep 22, 2022
A magic ligand and catalyst towards industrial scale C-H hydroxylation at room temperature with aqueous H2O2: pubs.acs.org/articlesonrequ…. JACS Video: vimeo.com/acs/review/752…
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Yulab
@YulabJin
Oct 4, 2023
Presenting my 20 year progress on enantio CH activation in front of my mentor Professor Corey, and teacher Eric Jacobsen who taught me organometallic class then. Photo 1 siting next to my mentor getting ready; photo 2 feeling spoiled when Eric presented the Tishler Prize medal.
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Yulab
@YulabJin
May 26, 2022
Finally, a man-made catalyst for gamma methylene CH! Double bond and carbonyl alpha chemistry build 1,2-relationship well, now via beta and gamma CH , we provide new disconnections for 1,3 and 1,4. Many new reactions are coming soon. science.org/doi/10.1126/sc…
Yulab
@YulabJin
May 16, 2024
Since Enantioselective beta C-H activation in 2016, we have chased gamma and delta relentlessly, finally: science.org/doi/epdf/10.11…
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Yulab
@YulabJin
Sep 7, 2023
Developed H-donor catalyst for recruiting COOH, now H-acceptor catalyst for binding OH, Nature: 10.1038/s41586-023-06485-8. Enzymes can use multiple contact points to direct, we only have one, thus needs precise distance and geometry.@JacobsenLab @HoveydaLab @MillerGroupYale
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Yulab
@YulabJin
Oct 15, 2021
Meta-cyclophane transition state strike another gold in CHfunctionalization:Remote directing like enzymes, nature Chem ASAP
Yulab
@YulabJin
Aug 9, 2022
Bond by bond Molecular editing of C3-C7 was daunting, to reverse the order looked impossible as we call this Apollo 17 moonshot. In addition to distance and geometry, we used chiral recognition to realize this feat for the first time, @nature
Yulab
@YulabJin
May 31, 2023
Distance & geometry is emerging as key principle for ligand design to lower prohibitive TS. Molecular editing of saturated rings is made possible. Nature asap: rdcu.be/ddrPV. Licensed to the newly founded ArCHitect Therapeutics.
33K
Yulab
@YulabJin
May 11, 2023
Alternative [2+2] for BCB scaffold via two sp3 CH and two ArX bonds, not starting from pi orbitals. Ligand innovation is the key: science.org/doi/10.1126/sc…
25K
Yulab
@YulabJin
Aug 26, 2024
Yamada-Koga asymmetric lithiation is part of the inspiration for our first project on asymmetric CH palladation in 2002. This recognition is so special to my coworkers: CH activation is finally a significant member of the asymmetric catalysis family, huge potential to yet improve
9.4K
Yulab
@YulabJin
Jun 6, 2020
The views expressed in the Hudlicky ACIE paper are unacceptable. As an immigrant to America I know the damaging effects of discrimination. I value diversity in the sciences, and want my students and colleagues to succeed regardless of gender, race, or sexual orientation.
Yulab
@YulabJin
Mar 9, 2022
As promised, we are coming to hug gamma CH, methyl this time, soon will be methylene. Once again, all controlled by Distance and Geometry, not by stereo/electronic effects @J_A_C_S
Yulab
@YulabJin
Jul 7, 2020
Our 100th JACS on C-H is the 100th small step towards protecting group free Enantio-CH activation: pubs.acs.org/doi/pdf/10.102…
Yulab
@YulabJin
Jan 9, 2025
A magic spoon of table salts for aliphatic acids in 2007 guided us along the path of CH activation based on weak coordination, leading to discoveries of 10 distinct classes of bifunctional ligands so far, but ketones are too slippery until now: Nature: 10.1038/s41586-024-08281-4
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