Medha Agarwal

@mkhandel

General Partner @Defyvc. inception, seed + Series A. Proud @HarvardHBS @Harvard @Redpoint @Radlwtcrew @Bainalerts alumna. Recovering New Yorker, loving SF

San Francisco, CA

makecents.substack.com

Joined April 2012

Pinned
Medha Agarwal
@mkhandel
Nov 20, 2023
1/ I’ve joined @defyvc as a General Partner! Excited to work alongside the rest of the Defy team to support the next generation of incredible founders and category defining companies. I’ll be focusing on investing from inception through Series A.
Medha Agarwal
@mkhandel
Jun 9
One of the more interesting things happening in vertical AI right now isn't the technology itself. It's the return of old-school sales. For the last decade, software companies optimized around relatively small ACVs. The playbook was PLG, SDRs, content, and efficient digital
Medha Agarwal
@mkhandel
May 12
Thrilled to share that @champ_hq AI is officially out of stealth with $8.5M in funding! 🎉 We @defyvc have had the privilege of working with @jputrevu, @HeyTedC, and @ptrln since they were hardening their thesis on day -1 and I couldn't be more excited about what's ahead. These
Medha Agarwal
@mkhandel
Feb 22
Very cool opportunity. Can't wait to meet the next generation of Neo founders! @apartovi @neo
Neo
@neo
Feb 20
Today we unveiled Neo Residency, a new program for startups and high-agency student teams. 🎉 We’re replacing our best-known program, Neo Accelerator, with something even better and more selective. 🧵
Medha Agarwal
@mkhandel
Dec 15, 2025
Most AI startups over-optimize pre-sales GTM. The real failure point is after the contract is signed. Buying ≠ adopting. @nxh_lxn and I write about what we are seeing @defy_vc in Post-Sales GTM — and why renewals, expansion, and real value aren’t automatic in AI. The