Welcome to the
Pascoal Lab
About the
Lab
Our lab is interested in the quantification of brain pathophysiology in patients with Alzheimer’s disease (AD) and related dementias as well as in the validation of therapies capable of modifying the course of these diseases producing an enduring disease-modifying and clinically relevant effect. This involves the validation of positron emission tomography (PET) and fluid biomarker techniques capable of measuring these brain pathologies and monitoring their progression.
Research in
Focus
Recent
Publications
Nature Communications
Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer’s disease
Alzheimer’s & Dementia
Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer’s disease
Alzheimer’s & Dementia
Impact of the polygenic risk scores for attention-deficit/hyperactivity disorder in Alzheimer’s disease
JAMA Network
Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease
Nature Aging
APOEε4 potentiates amyloid β effects on longitudinal tau pathology
Alzheimer’s & Dementia
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals
Stay Tuned
News
Funding
Affiliations
Funding
Affiliations
