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Roger Greenberg
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Roger Greenberg

@RogerRogergr
The Greenberg lab investigates processes that affect genome integrity and how they influence human biology
The University of Pennsylvania, Philadelphia, PA
med.upenn.edu/apps/faculty/i…
Joined October 2017
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  • user avatar
    Roger Greenberg
    @RogerRogergr
    Jul 6
    Congratulations to Arindam Datta @arindam_datta1 on publication of “The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells”.
    nature.com
    The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells
    Nature Communications - ATM kinase activity is required for cellular survival to replication fork damaging chemotherapies. Here the authors show that deficiency in the BRCA1-A complex promotes...
  • user avatar
    Roger Greenberg
    @RogerRogergr
    Jun 16
    Thrilled to announce that postdoc, Haoyang Jiang, has been awarded an NCI Pathway to Independence Award (K99/R00) for his project, "BLM-Driven Recombination at Alternative Lengthening of Telomeres and Non-Telomeric Sites." Congratulations Haoyang on this well deserved award!
  • user avatar
    Roger Greenberg
    @RogerRogergr
    Mar 21
    Great work in Mol Cell from John Maciejowski's group delineating BAF dependent regulation of TREX1 and cGAS in micronuclei. Very important implications for immune responses to chromosome instability. cell.com/molecular-cell…
  • user avatar
    Roger Greenberg
    @RogerRogergr
    Aug 22, 2025
    Please see our review article in NSMB, “Mechanisms and genomic implications of BIR”. Adel Atari and @HaoyangJiang2 focus on mammalian BIR, its relationships to human disease, and genome engineering. Thanks to reviewers for helpful comments. nature.com/articles/s4159…
  • user avatar
    Roger Greenberg
    @RogerRogergr
    Mar 17, 2025
    Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors rdcu.be/edRwF. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.

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