Resources Library
Learn More About Everything MRR
Explore educational content, technical resources, and expert insights to help you learn more about molecular rotational resonance (MRR) spectroscopy and its applications. Browse our collection of brochures, application notes, posters, videos, webinars, and publications.
Brochures
Learn about BrightSpec's instruments, technology, and solutions for structure identification and quantitation.
Brochure
Meet the Full BrightSpec-MRR Product Portfolio
Explore the complete product line for structure identification and quantitation.
Brochure
Meet the spectraMRR
Application Notes
See how MRR addresses real-world analytical challenges across a wide range of industries and applications.
App Note
Direct Quantitation of Ethylene Glycol in a mAb Formulation Matrix by MRR
October 2026
Measure ethylene glycol directly in a complex biologic matrix.
App Note
Single-Method Quantitation of Chemically Diverse Residual Solvents by Molecular Rotational Resonance: Application to Peppermint Oil
October 2026
Quantify four residual solvents in peppermint oil using a single direct-injection workflow.
App Note
Accelerating Forced Degradation Studies with Molecular Rotational Resonance Spectroscopy: Targeted Analysis of Caffeic Acid Degradation Products
July 2026
Speed degradation product characterization and impurity profiling.
App Note
Rethinking Routine Quality Control for Food & Beverage: Direct Analysis of Representative Volatile Quality Markers in Fortified Wine
July 2026
Analyze key quality markers without burdensome sample preparation.
App Note
Structure-Specific Identification of Impurities in Complex Mixtures Using MRR
June 2026
Differentiate closely related impurities with confidence.
App Note
Unambiguous Identification of Candidate Compounds Using MRR Structure Validation
May 2026
Confirm candidate structures through spectral matching.
App Note
Structure Validation: Automated MRR Library Building for Confident Molecular Identification
April 2026
Generate validated spectral libraries for future analyses.
App Note
Direct Quantitative Analysis of Formaldehyde in Aqueous Samples Using MRR with SpectrAline Cartridges and the spectraMRR
March 2026
Quantify formaldehyde in water without derivatization.
App Note - Structure ID
Same Formula, Different Story: Unambiguous Identification of Stereoisomers Using Molecular Rotational Resonance Spectroscopy
February 2026
Distinguish stereoisomers that share the same formula.
App Note
Where Precision Meets Throughput: Molecular Rotational Resonance Spectroscopy for Ethylene Glycol and Diethylene Glycol Excipient Safety Testing
December 2025
Screen for EG and DEG contaminants with minimal sample preparation.
App Note
Formaldehyde: How BrightSpec's nanoMRR Measures Challenging Chemicals
December 2025
Enable rapid formaldehyde analysis with a streamlined workflow.
App Note
Tracking Ethylene Oxide and Acetaldehyde in PEG-3350: How Molecular Rotational Resonance Spectroscopy Outpaces Gas Chromatography
October 2025
Compare impurity testing workflows for PEG-3350 analysis.
App Note
Beyond Mass: Structure-Specific Quantitation of Closely Related Impurities in Pharmaceutical Raw Materials
August 2025
Quantify closely related impurities using structural information.
App Note
Breaking the Standard: Alaninol Chirality Confirmed Without Chromatography
June 2025
Verify chirality without chromatographic separation.
App Note
Ditching Derivatization: Molecular Rotational Resonance Spectroscopy for Formaldehyde Quantitation
May 2025
Eliminate derivatization while maintaining quantitative performance.
App Note
No Standards, No Problem: Molecular Rotational Resonance Spectroscopy Cracks the Chiral Code
April 2025
Determine chiral composition without reference standards.
App Note
Molecular Rotational Resonance Spectroscopy: An Agile Solution for Residual Analysis in Pharmaceutical Products
March 2025
Simplify residual solvent analysis in pharmaceutical products.
App Note
Unmasking Essential Oil Authenticity with Molecular Rotational Resonance Spectroscopy
February 2025
Verify essential oil authenticity with molecular specificity.
App Note
Direct Analysis of Class 2 Residual Solvents Using Molecular Rotational Resonance Spectroscopy
February 2025
Streamline Class 2 residual solvent testing with direct analysis.
Scientific Posters
Browse scientific posters featuring MRR research, application data, and conference presentations.
Poster
Streamlined Impurity Characterization Through Molecular Rotational Resonance for Isomer Discrimination
October 2026
Differentiate challenging isomers with confidence during impurity characterization.
Poster
Bridging Gaps for Analysis of Challenging Residual Solvents Using MRR
October 2026
Overcome analytical gaps in residual solvent testing with direct molecular identification.
Poster
Enabling High-Throughput Natural Product Identification through Molecular Rotational Resonance (MRR) Spectral Libraries
July 2026
Accelerate terpene and natural product identification with validated spectral libraries.
Poster
Standards-Free Structural Elucidation of Natural Products Using Molecular Rotational Resonance (MRR) Spectroscopy
July 2026
Accelerate structural elucidation and impurity profiling of natural product mixtures.
Poster
Unambiguous Structural Identification Without Reference Standards Using MRR
June 2026
Identify and differentiate isomers without reference standards.
Poster
Differentiation of Isomeric Anilines & Pyridines by Targeted Molecular Rotational Resonance Spectroscopy & Mass Spectrometry
June 2026
Compare MRR and mass spectrometry for isomer discrimination.
Poster
Direct Headspace-MRR Quantitation of Ethylene Glycol & Diethylene Glycol Contaminants in Glycerin
June 2026
Detect EG and DEG contaminants with minimal sample preparation.
Poster
Routine Characterization of Enantiomerically Selective Reactions by Molecular Rotational Resonance (MRR) Spectroscopy
March 2026
Monitor chiral reactions through structure-specific analysis.
Poster
Development of a Spectral Library for Nitrosamine ID and Quantification in Pharmaceuticals and Consumer Products
March 2026
Enable nitrosamine identification and quantitation using validated spectral libraries.
Poster
High-Throughput, Fully Automated Analysis of USP <467> Residual Solvents Using Headspace MRR
March 2026
Automate residual solvent analysis without chromatographic separation.
Videos
Watch MRR technology, workflows, and applications brought to life through visual demonstrations and expert insights.
Video
Molecular Rotational Resonance Spectroscopy Overview
See BrightSpec's molecular rotational resonance (MRR) spectroscopy technology in action and learn how it enables direct molecular identification and quantitation from a single measurement.
Video
Meet the spectraMRR
Explore BrightSpec’s spectraMRR™, an advanced molecular rotational resonance (MRR) spectroscopy platform that simplifies structure analysis and delivers highly selective molecular identification and quantitation.
Video
Meet the isoMRR
Discover BrightSpec's isoMRR™, a powerful platform for precise quantification of volatile compounds, delivering confident analysis of isomers and enantiomers in a single streamlined workflow.
Video
Meet the nanoMRR
See how BrightSpec is making chemical analysis faster and more accessible with a compact MRR platform that provides confident identification and quantification in minutes.
Video
Unique Detection for Diastereomers
Learn how molecular rotational resonance (MRR) spectroscopy distinguishes closely related diastereomers that are often difficult to differentiate using traditional methods such as gas chromatography.
Webinars
Gain deeper insight into MRR through on-demand presentations from BrightSpec scientists and industry experts.
Webinar
Rethinking Targeted Analysis: Structure-Specific Detection in Complex Food & Pharmaceutical Matrices
September 2026
Learn how MRR leverages molecular structure to distinguish compounds that conventional approaches struggle to differentiate.
Webinar
Fast & Reliable Quantitation of Challenging Residual Solvents in Dietary Supplements Using MRR
September 2026
Webinar
Direct Highly Selective Analysis of Ethylene Oxide & Acetaldehyde in Challenging Samples Using MRR
September 2026
Webinar
MRR for Faster, Simpler Detection of Volatile Food Contaminants in Complex Matrices
July 2026
Watch how MRR spectroscopy gives food and beverage quality and safety teams a faster, simpler, and smarter way to identify volatile compounds, even in complex matrices.
Webinar
Using the nanoMRR in Teaching and Research: A Chemistry Professor's Guide
February 2025
Discover how BrightSpec's nanoMRR instrument, powered by molecular rotational resonance, is being used in academic research and teaching.
Webinar
Unveiling Sesquiterpenes: Characterizing Isomers with MRR Spectroscopy
May 2022
See how MRR can characterize the stereoisomers of sesquiterpenes without the need for reference samples.
Webinar
Everyday Authenticity: A Novel Approach to Tea Tree Oil Characterization
February 2022
Learn how MRR can be used to validate product authenticity and improve product quality.
Webinar
Application of MRR Spectroscopy in Drug Development
June 2021
GlaxoSmithKline Pharmaceuticals presents how structural analysis with MRR simplifies chemical analysis during pharmaceutical drug development.
Webinar
MRR - A Powerful Analytical Technique for Industrial Chemistry
March 2021
BASF presents how MRR fits into their analytical toolkit and provides a powerful orthogonal approach.
Webinar
Introduction to MRR Principles and Instrumentation
March 2012
Our CTO, Justin Neil, PhD, gives an introduction to the foundational principles of molecular rotational resonance spectroscopy.
Publications
Read peer-reviewed research highlighting the science, developments, and capabilities of MRR spectroscopy.
Publication
A Semi-Automated Workflow for Molecular Rotational Spectroscopy Characterization of New Molecules
October 2026 Journal of Molecular Spectroscopy
Accelerate the identification and characterization of new molecules.
Publication
Unravelling the Enantiomeric Distribution of Key Sandalwood Sesquiterpenoids by Enantioselective Gas Chromatography & Molecular Rotational Resonance
September 2026 Journal of Natural Products
Reveal the chiral composition of sandalwood oil components.
Publication
Perfluorooctanoic Acid Monohydrate (PFOA-H2O) Studied by Molecular Rotational Resonance (MRR) Spectroscopy
April 2026 Chemical Physics Letters
Gain insight into the structure of hydrated PFAS compounds.
Publication
Semi-Reduction of Allenes to Access Deuterated Allylic Isotopomers, Isotopologs & Enantioisotopomers
February 2026 Angewandte Chemie
Enable the preparation of well-defined chiral isotopomers.
Publication
Segmental Deuterium Labeling of Alkyl Chains by Nickel–Mediated Desulfurization
October 2025 Asian Journal of Organic Chemistry
Demonstrate precise and selective deuterium incorporation.
Publication
Studies in Enantioselective Microbial Deuteration
March 2025 Organic & Biomolecular Chemistry
Explore biological approaches to selective isotope labeling.
Publication
How MRR Spectroscopy Overcomes MS, GC Challenges
October 2024 labcompare
Address analytical challenges that limit traditional techniques.
Publication
Application of Laser-Induced Acoustic Desorption for Molecular Rotational Resonance Spectroscopy
April 2024 Analytical Chemistry
Extend analysis to compounds that are difficult to volatilize.
Publication
An Automated, Highly Selective Reaction Monitoring Instrument Using Molecular Rotational Resonance Spectroscopy
February 2024 Precision Chemistry
Enable automated monitoring of chemical reactions.
Publication
Absolute Configuration Assignment of Highly Fluorinated Carboxylic Acids via VCD & MRR Spectroscopy
February 2024 Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Determine stereochemistry in highly fluorinated molecules.
Publication
Essential Oil Composition & Enantioselective Profile of Juniperus communis var. depressa (Cupressaceae) from Utah
July 2023 Journal of Essential Oil & Plant Composition
Characterize chiral constituents in natural products.
Publication
Assignment of the Absolute Configuration of Molecules that are Chiral by Virtue of Deuterium Substitution Using Chiral Tag Molecular Rotational Resonance Spectroscopy
June 2023 Chirality
Determine molecular handedness through isotopic substitution.
Publication
Analysis of Isomeric Mixtures by Molecular Rotational Resonance Spectroscopy
May 2023 Analytical Science Advances
Distinguish and quantify challenging isomer mixtures.
Publication
Precision Deuteration Using Cu-Catalyzed Transfer Hydrodeuteration to Access Small Molecules at the Benzylic Position
May 2023 Journal of the American Chemical Society
Achieve targeted isotope placement with high precision.
Publication
Rapid Enantiomeric Excess Measurements of Enantioisotopomers by MRR Spectroscopy
March 2023 Organic Process Research & Development
Enable accurate determination of enantiomeric purity.
Publication
Essential Oil Composition & Enantioselective Profile of Agastache urticifolia (Lamiaceae) & Monardella odoratissima (Lamiaceae) from Utah
February 2023 Molecules
Compare chiral profiles across mint varieties.
Publication
Direct Construction of Peaks from Free Induction Decay Curves for Gas Chromatography–Molecular Rotational Resonance Spectroscopy without Fourier Transforms
October 2022 Analytical Chemistry
Simplify data processing for GC-MRR analysis.
Publication
Enantioselective Synthesis of Enantioisotopomers with Quantitative Chiral Analysis by Chiral Tag Rotational Spectroscopy
June 2022 Angewandte Chemie
Combine enantioselective synthesis with precise chiral measurement.
Publication
Chiral Analysis of Linalool, an Important Natural Fragrance and Flavor Compound, by MRR Spectroscopy
April 2022 Symmetry
Evaluate chirality in a key flavor and fragrance ingredient.
Publication
Enhancing Sensitivity for High-Selectivity Gas Chromatography-MRR Spectroscopy
November 2021 Analytical Chemistry
Improve detection of low-level compounds.
Publication
Conformational Dynamics of Perfluorooctanoic Acid (PFOA) Studied by Molecular Rotational Resonance (MRR) Spectroscopy
September 2021 Chemical Physics Letters
Explore the structural behavior of PFAS molecules.
Publication
Chiral Analysis of Pantolactone with Molecular Rotational Resonance Spectroscopy
September 2021 Chirality
Rapidly assess enantiomeric composition.
Publication
Copper-Catalyzed Transfer Hydrodeuteration of Aryl Alkenes with Quantitative Isotopomer Purity Analysis by Molecular Rotational Resonance Spectroscopy
May 2021 Journal of the American Chemical Society
Verify isotopic purity following synthesis.
Publication
Rapid Quantification of Isomeric & Dehalogenated Impurities in Pharmaceutical Raw Materials Using MRR Spectroscopy
September 2020 Journal of Pharmaceutical & Biomedical Analysis
Measure difficult pharmaceutical impurities with confidence.
Publication
Direct Regioisomer Analysis of Crude Reaction Mixtures via Molecular Rotational Resonance (MRR) Spectroscopy
June 2020 Chemical Science
Analyze regioisomers directly from reaction mixtures.
Publication
Preparation of Cyclohexene Isotopologues & Stereoisotopomers from Benzene
May 2020 Nature
Generate well-defined isotopic and stereochemical variants.
Publication
A Gas Chromatography-Molecular Rotational Resonance Spectroscopy-Based System of Singular Specificity
October 2019 Angewandte Chemie
Demonstrate exceptional molecular selectivity.
Publication
Rotational Spectroscopy of Imidazole: Improved Rest Frequencies for Astrophysical Searches
August 2019 Astronomy & Astrophysics
Improve molecular data for astrochemical studies.
Publication
Direct Measurements of Small Polar Impurities in Gasoline Mixtures Using Molecular Rotational Resonance Spectroscopy
June 2019 Applied Spectroscopy
Detect trace polar contaminants in fuel samples.
Publication
Online Stereochemical Process Monitoring by Molecular Rotational Resonance Spectroscopy
April 2019 Organic Process Research & Development
Monitor stereochemical outcomes in real time.
Publication
Quantitative Chiral Analysis by Molecular Rotational Spectroscopy
June 2018 Chiral Analysis
Directly quantify chiral composition.
Publication
Molecular Structure & Chirality Detection by Fourier Transform Microwave Spectroscopy
December 2014 Journal of Physical Chemistry Letters
Determine structure and chirality simultaneously.
Publication
Water–Water & Water–Solute Interactions in Microsolvated Organic Complexes
November 2014 Angewandte Chemie
Reveal how water influences molecular interactions.
Publication
Broadband Fourier Transform Rotational Spectroscopy for Structure Determination: The Water Heptamer
May 2013 Chemical Physics Letters
Reveal the structure of complex water clusters.
Publication
Structures of Cage, Prism, & Book Isomers of Water Hexamer from Broadband Rotational Spectroscopy
May 2012 Science
Differentiate distinct water cluster structures.
Publication
Rotational Spectroscopy of Iodobenzene & Iodobenzene–Neon with a Direct Digital 2–8 GHz Chirped-Pulse Fourier Transform Microwave Spectrometer
September 2011 Journal of Molecular Spectroscopy
Characterize molecular and weakly bound complexes.
Publication
Design & Evaluation of a Pulsed-Jet Chirped-Pulse Millimeter-Wave Spectrometer for the 70-102 GHz Region
June 2011 Journal of Chemical Physics
Advance instrumentation for high-resolution spectroscopy.
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