The primary endpoint in the HBeAg+ part is HBVDNA... Pevifoscorvir sodium is a potent potential best/first-in-class oral small molecule capsid assembly modulator (CAM-E) being developed for chronic hepatitis B virus (HBV) infection.
Cohort 4 evaluated a novel sequential combination treatment strategy for HBV utilizing Brii Bio's therapeutic vaccine, BRII-179, to prime and enrich participants with a goal of improving responsiveness to curative therapies.
The ELIMINATE-B trial is evaluating PBGENE-HBV for the treatment of chronic hepatitis B ... About PBGENE-HBV, A Viral EliminationProgram ... Elimination of cccDNA results in HBV viral cure as cccDNA is the only source of infectious replication (HBV DNA).
...Hepatitis B, cccDNA, while inactivating integrated HBVDNA; and the expectation that elimination of cccDNA could result in HBV cure as cccDNA is the only source of infectious replication (HBV DNA).