Pinned
Affinity maturation is how naive antibodies evolve into strong binders, but most antibody LMs ignore it.
@stephenzlu and I built CoSiNE to learn this, beating antibody LMs on VEP and reframing design as guiding evolution, not de novo generation.
Excited to present at ICML!
Antibody LMs learn what looks antibody-like, but not how selection turns naive germline antibodies into strong binders.
@aakarshv1 and I are excited to share CoSiNE, a model that learns this germline-to-mature process for variant effect prediction and antibody design. (1/8)
