Eterna (@eternagame) / X

Eterna

945 posts

Eterna

@eternagame

Eterna is a videogame where you can invent medicine. You solve RNA design puzzles, and your solutions get synthesized and tested by biochemistry & robotics!

Stanford, CA

Joined October 2010

Eterna
@eternagame
Jul 23
OpenKnot Round 9 features secondary structures designed by players to create compact, pseudoknotted RNA using 240 bases. GenAI teams also will test whether their methods perform as well as the expert players at a longer length. Check out the puzzle at: eternagame.org/labs/14343053
Eterna
@eternagame
Jul 17
Eternacon 12 will be Sunday, July 26, 9am to 2pm PT featuring talks on player pseudoknot design techniques, the Montparnasse algorithm solving the Eterna100, an RNA scaffold for cryo-EM, and results for our pilot Replicase puzzle. Free to register at eternagame.org/eternacon/2026
Eterna
@eternagame
Jul 7
Eterna's newest puzzle challenges players to design 240-base RNA strands that will fold into compact pseudoknots. The puzzle provides a metric for counting the number of pairs that cross to form large, synthetic pseudoknots. Check out the puzzle at eternagame.org/labs/14333719
Eterna
@eternagame
Nov 27, 2025
A new 3-state Replicase challenge has been launched on Eterna and will only be open for two weeks before sequences are collected for experimental testing at @RDasLab. Will Eterna players be able to improve the catalytic activity of the RNA polymerase? eternagame.org/labs/14183416
Eterna
@eternagame
Sep 29, 2025
In addition to the RibonanzaNet server hosted by @RDasLab, RNA structure fans can try the new pseudoknotted prediction model in Eterna's RNet Study collection. The 108 puzzles are a mix of experimentally-validated structures and synthetic fabrications. eternagame.org/collections/13…
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