We are recruiting a group leader in quantitative or computational biology. 9 years of core funding and freedom to do something important. Probably the best combination of genomics, quantitative and mechanistic biology in Europe. Deadline soon! pls RT
nature.com/naturecareers/…
Truly delighted to welcome @BenLehner to the Human Genetics faculty at @sangerinstitute. I’ve long been a fan of Ben’s creative and wide-ranging science and we are all really excited to work with him over the coming years.
We are thrilled to launch our new programme, Generative and Synthetic Genomics! 🎉
Led by @BenLehner, we’ll use big #data & #AI to understand & predict the effects of mutations, and engineer biological systems 🧬
With support from @wellcometrustsanger.ac.uk/news_item/pred…
Excited to start recruiting postdocs + research assistants to my lab @sangerinstitute
Massive mutagenesis to make biophysics + human genetics predictive? allostery, affinity, stability, splicing, receptors, TFs, cancer. pls RT
tinyurl.com/bmb9vv5stinyurl.com/49f3ubc3
One huge structural problem of Catalan/Spanish research is the non-diverse leadership. Institute directors, heads of funding bodies, senior faculty are nearly all Spanish (+ men). It is not like this in other countries. A system with such a bias cannot possibly be meritocratic.
The genetic architecture of protein stability
Experimental exploration of >10^10 sequence spaces => protein genetics is simple and intelligible
New pre-print by the formidable @aj4re, Aina Martí-Aranda, @cristonah, @JoernSchmiedel
Here it is: the allosteric map of a protein.
Want to find all the sites to target in your favourite undruggable protein? Here's how you can do it.
>22k biophysical measurements for one protein (KRAS)
Congratulations to @WengChenchun and @aj4re
Introducing the Domainome... Site saturation mutagenesis of 500 human protein domains reveals the contribution of protein destabilization to genetic disease by @ToniBeltran13 @CRGenomica@sangerinstitute @BGI_Genomics
