Aaron Ring (@aaronmring) / X

Aaron Ring

2,874 posts

Aaron Ring

@aaronmring

Associate Professor at @FredHutch Studying cytokines, (auto)antibodies, and cancer immunotherapy Founder: @SimchaTx, @Seranova, @StippleBio, and @AriaxBio

Seattle, WA

Joined December 2017

Pinned
Aaron Ring
@aaronmring
Jul 23, 2025
T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…
Aaron Ring
@aaronmring
Nov 16, 2020
The 94.5% efficacy of the $MRNA vaccine is getting the headlines, but its stability at -20˚C (normal freezer) long term and up to 30 days at 4˚C (normal fridge) are game changers.
Aaron Ring
@aaronmring
Mar 10, 2023
Replying to @SynthIge
I am the corresponding author of this study and what you claimed above is completely wrong . Not a single vaccinated individual in our study was noted to have developed a new "autoimmune disease." That is not what Fig. S4B shows.
Aaron Ring
@aaronmring
Jun 24, 2020
Our lab's first paper (rdcu.be/b49xK) is now out at @Nature. We found that the cytokine IL-18 can drive potent anti-tumor activity from the innate and adaptive immune system, but that its activity is restricted by a high-affinity "decoy receptor" IL-18BP. (1/)
Aaron Ring
@aaronmring
Sep 7, 2020
A modest proposal: instead of paying fake "tuition" for grad students off our grants, can we give them a much higher stipend?
Aaron Ring
@aaronmring
Sep 12, 2021
With PhD and MD/PhD admissions season kicking into gear, I have deeply mixed feelings about recruiting the next generation of trainees into the biosciences. Many do not realize that the biotech industry is in grave danger with vast swathes of research jobs in jeopardy.
Aaron Ring
@aaronmring
Sep 7, 2020
Is there a bigger scam than the requirement that labs have pay the university "tuition" for graduate students that are working full time in the lab (e.g., year 3 and up)? Why do the NIH and other funding agencies allow this? A pointless drain on research $$$ that makes no sense.
Aaron Ring
@aaronmring
May 5, 2025
Just a few months ago, the Baker and Garcia labs released con-concurrent preprints with incredible results. They designed de novo miniproteins that bound specific peptides presented in MHC-I. Now let me show how you can use BindCraft at @AriaxBio to do the same thing.
Aaron Ring
@aaronmring
Jan 9, 2022
Resign @CDCDirector. The American people deserve better than your record of incompetence, negligence, and now blatant apathy. Your job is to protect the vulnerable, not to consign them to death. What would be "encouraging" is your retirement.
Aaron Ring
@aaronmring
May 5, 2021
I'm astonished by how many people are buying the thinking that waiving vaccine IP will somehow magically increase vaccine supply. A patent is not a factory, personnel, a GMP process, and regulatory approval. It will take months to boot up even without supply chain shortages.
Aaron Ring
@aaronmring
Nov 24, 2022
The IL-18 armored CAR-T data from @carlhjune's group at ASH this year is remarkable (ash.confex.com/ash/2022/webpr…). 100% ORR so far, 7/8 patients had relapsed on a prior CAR-T product. IL-18 baby!!!
Aaron Ring
@aaronmring
Mar 3, 2022
Today I asked the Yale administration to suspend or cancel the Blavatnik Fund for Innovation at Yale in response to Russia’s wanton attack on Ukraine. Despite his insistence otherwise, Len Blavatnik is an oligarch whose fortune came through his close ties to the Kremlin. (1/2)
Aaron Ring
@aaronmring
Mar 9, 2023
How does primary SARS-CoV-2 infection compare to mRNA vaccination when it comes to autoantibody development? @_BlueJay3 led an effort with @VirusesImmunity and her lab and our @BRIseattle collaborators to answer this question:
SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity
From nature.com
Aaron Ring
@aaronmring
May 10, 2023
Twitter fam- big news for the lab... we will be moving to the @fredhutch this summer!