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Thrilled to share that I have joined @AnthropicAI as a life science researcher! I am confident that Claude will do amazing things to accelerate biology. Big things ahead!
- Today was my last day at the @arcinstitute. I was the first scientific hire in 2021. It was incredible to see the institute go from just an idea to world-class science in such a short period of time. Very grateful to have worked with so many amazing scientists on several
- What if you could recombine any two DNA sequences in a programmable manner? We discovered an RNA-guided recombinase that can do just that! So happy to have co-led this project with @ntperry13Just shared at @KeystoneSymp a new @arcinstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts
- The race is on to design a protein that tastes sweet!
- Our 2 bridge RNA papers are finally published in @Nature! Check out the incredible CryoEM structures, they're truly beautiful. A years-long rollercoaster ride, it's hard for me to imagine a more exciting project than this. Thank you to @ntperry13, @pdhsu, and our amazing team!What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
- Excited to announce that I’m starting a new position as a senior fellow @FutureHouseSF. I’ll be working on applying AI agents to metagenomic workflows. Very grateful for the opportunity to learn and explore my scientific interests. Please reach out if you’d like to collaborate!
- Thrilled to see this published! It was great working on this project with @JoshTycko, @AlisonFanton, @pdhsu, @BintuLacra, Mike Bassik, Ami Bhatt and others these past few years. It has definitely been the highlight of my scientific career!
- It is crazy how many incredible scientists are looking for jobs right now.
- AI guy learning about biology for the first time: Getting a lot of 'AI' vibes from this.
- Everyone wants to replicate the Bell Labs model, minus the nearly unlimited funding from a decades-old government-sanctioned monopoly.well, here we go. @sama, Masa and others are backing new company trying to become a Bell Labs for the modern age. scoop here - corememory.com/p/exclusive-al…
- Bridge RNAs are the likely ancestor of eukaryotic snoRNAs! Really exciting evolutionary analysis from the @shsternberg lab. Awesome to see that IS110 transposons may have played a key role in the evolution of complex life! So much to learn.
- This paper is a fun read, an interesting bioinformatics and engineering problem to wrap your head around.
- Protein structure prediction and protein design is evolving so quickly that I don't know what tools I should be using.
- Hey folks, I know most deadlines are fast approaching, but I am applying for assistant professor positions this cycle, and I would appreciate recommendations for open positions! My research plan is focused on MGEs, genome engineering, and applying AI to biological discovery.
