Brunet Lab (@BrunetLab) / X

Brunet Lab

2,296 posts

Brunet Lab

@BrunetLab

Aging lab @Stanford - Epigenomics and metabolism in #aging; Brain aging and rejuvenation; Neural stem cells; C. elegans; African #killifish

Stanford, CA

web.stanford.edu/group/brunet/

Joined March 2010

Brunet Lab
@BrunetLab
Oct 3, 2024
Can we use CRISPR screens to identify genes that drive neural stem cell aging? Super excited to see this work published @Nature! Huge congrats to Tyson @ruetz_tyson, Angie Pogson, @kashiwagi_chloe, and all authors! Great collaboration with @MCBassik!
CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells
From nature.com
67K
Brunet Lab
@BrunetLab
Mar 30, 2024
Incredibly excited to share our paper on the impact of partial reprogramming on neurogenic niches of the old brain (in mice)!! Massive congratulations to first-author Lucy Xu and all the authors!! 🌟🙌🍾
Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche
From nature.com
118K
Brunet Lab
@BrunetLab
Feb 21, 2020
Very excited that our study on the African killifish diapause is out today!! Huge congrats to Chi-Kuo Hu for spearheading all this! Also, many thanks to all contributors - @param_p_singh, @Planaria1 and others :) Diapause - a thread! 1/n science.sciencemag.org/content/367/64…
Brunet Lab
@BrunetLab
Jul 14, 2023
Incredibly excited to share our paper on chromatin changes in neural stem cells during aging It revealed defects in cell migration with age! CONGRATS to @robinwyeo and @OliviaYZhou! Awesome collaboration with @anshulkundaje and @Dunn_Lab! 🎉🥂
Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell...
From nature.com
62K
Brunet Lab
@BrunetLab
Sep 22, 2022
How do males shorten the lifespan of the opposite sex? (in worms) nature.com/articles/s4358… HUGE CONGRATS to Lauren Booth @lnbooth (now at Calico!) 🎉🍾⭐️ 👏 It's so awesome to see this paper out @NatureAging!!! A fun collaboration with Coleen Murphy's lab @ctmurphy1!
Brunet Lab
@BrunetLab
Dec 20, 2022
Can we build 'aging clocks' in different cell types to measure the impact of aging and 'rejuvenation'? ⏲️ Massive congrats to @MatttBuckley and @EricDSun!🍾🎉🙌 rdcu.be/c1TPK @NatureAging Great collaboration with #IrvWeissman @wysscoray @Goodell_Lab @Thomas_Rando!
44K
Brunet Lab
@BrunetLab
Jan 13, 2022
Excited to report that our paper on single-cell based 'aging clocks' for regenerative regions of the brain is on bioRxiv! HUGE congrats to Matt @MatttBuckley and Eric @EricDSun and to our fantastic collaborators at Baylor, UCLA, and Stanford! 🎉 A 🧵 biorxiv.org/content/10.110…
Brunet Lab
@BrunetLab
Oct 24, 2019
Our latest paper on aging fibroblasts is out! Thrilled to see the work published and huge congratulations to @Salah__Mahmoudi and all authors! In this work, we were curious about the changes in fibroblast populations during aging -1/8 (a thread!) nature.com/articles/s4158…
Brunet Lab
@BrunetLab
May 29, 2024
Beyond thrilled to share 3 papers on the killifish from our lab and fantastic collaborators!! 🐟🙌 Two on protein aggregates during aging – with @JaroszLab! cell.com/developmental-… cell.com/cell-reports/f… One on evolution of 'suspended animation'! cell.com/cell/fulltext/…
35K
Brunet Lab
@BrunetLab
Aug 19, 2022
Incredibly excited to share our new manuscript on the role of complex lipids during aging!! Massive congrats to Xiaoai @xiaoaizh for a tour-de-force, and a huge thank you to all authors and collaborators! biorxiv.org/content/10.110…
Brunet Lab
@BrunetLab
May 2, 2023
Thrilled to share our new paper on how specific dietary lipids extend lifespan!! Huge congrats to Katha @KPapsdorf and all the authors!! Awesome collaboration with @SJD956, @SnyderShot, @mengwang939, and @William_Mair! doi.org/10.1038/s41556… A 🧵...
35K
Brunet Lab
@BrunetLab
Nov 24, 2021
Thrilled to report our latest work on CRISPR-Cas9 screens to boost neural stem cells in old brains!! biorxiv.org/content/10.110… Massive CONGRATS to Tyson @ruetz_tyson and team for this tour de force and exciting results!!! 🙌 A thread (1/10):
Brunet Lab
@BrunetLab
May 17, 2023
Very excited to share our recent paper on precise genome engineering in the killifish! Massive congrats to @clairebedbrook, @Ravi__Nath, and Rahul! Awesome collaboration with @KarlDeisseroth doi.org/10.7554/eLife.… @eLife
47K
Brunet Lab
@BrunetLab
Jan 6, 2019
Cave fish have a mutation in the insulin receptor that makes them fat and helps them survive famine. The same mutation leads to insulin resistance and diabetes in humans. How do cavefish avoid the deleterious effects of insulin resistance? Cool study!! disq.us/t/30mlvso