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E. John Wherry
@EJohnWherry
Immunologist at University of Pennsylvania
Joined July 2013
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    E. John Wherry
    @EJohnWherry
    Jan 4, 2021
    Delay vaccine 2nd dose? Data from Pfizer/BioNTech. After 1 dose ~100-fold lower neut Ab. 4/15 @ 30ug have none. 12/15 @ 10ug have none. Unclear if more Ab develops later. Also lowering the dose might not be great either. Note: Viruses love to evolve under partial immune pressure!
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    E. John Wherry
    @EJohnWherry
    Dec 31, 2021
    There is no need to worry about exhaustion from a 4 vaccine dose. This is not how exhaustion works. Chronic infection with SARS-CoV-2 - that could give you exhaustion and is much (MUCH) more likely if you are unvaccinated.
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    E. John Wherry
    @EJohnWherry
    Jan 19, 2023
    One of the most impressive T cell papers in the past decades. A truly humbling experiment and incredibly important insights into T cell biology. @Masopust_Vezys truly amazing. A must read for all T cell biologist (all immunologists really). #instantclassic
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    Functional T cells are capable of supernumerary cell division and longevity
    From nature.com
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    E. John Wherry
    @EJohnWherry
    Dec 10, 2020
    Not all vaccine side effects are bad! Injection site soreness, myalgia & fever are a sign the Immune System is working! These are "on target" effects. Unexpected, dangerous side effects should be carefully monitored. But good vaccines can, will, & should induce immune reactions
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    E. John Wherry
    @EJohnWherry
    Jul 15, 2020
    Our paper on a detailed look an immunotypes in acute COVID-19 patients is out. Amazing team effort - so proud of all the authors involved here. Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications science.sciencemag.org/content/early/…
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    E. John Wherry
    @EJohnWherry
    May 24, 2020
    Our new study on immune profiling in COVID19 patients is on bioRxiv. An amazing effort by an amazing group of scientists. Not all patients respond the same way: 3 Immunotypes defined related to disease features and severity. #ImmuneHealth @Penn_IFI biorxiv.org/content/10.110…
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    E. John Wherry
    @EJohnWherry
    Feb 25, 2021
    Excited to share our new in vivo CRISPR screening system to interrogate T cell exhaustion. Great collaboration with the amazing @junwei_s spearheaded by @ZeyuCHEN19. In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
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    In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
    From cell.com
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    E. John Wherry
    @EJohnWherry
    Jul 26, 2021
    Sometimes it looks like Exhausted CD8 T cells recover from exhaustion - cell surface phenotype, even RNA and scRNA..But underlying epigenetics of exhaustion can be retained, impacting future responses. Epigenetics Scarring - new work by @M_S_Hakeem nature.com/articles/s4159…
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    E. John Wherry
    @EJohnWherry
    Apr 21, 2022
    Today we sent a letter to FDA with >60 signatories advocating for FDA guidance in assessing T cell responses in COVID vaccine studies. T cell immunity is likely a major player in protection from disease. We should analyze T cells (with Abs and memory B cells) across studies.
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    E. John Wherry
    @EJohnWherry
    Apr 23, 2022
    Early morning flight. KN95 for sure. Only ~30% masked here at PHL. Expect another viral blip in about 2 weeks. But don’t worry- no one will get sick. No one will get long COVID. Your employees will not call out sick for weeks…
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    E. John Wherry
    @EJohnWherry
    Oct 2, 2023
    Last week we had a 75th bday symposium for my mentor Rafi Ahmed. His closing words should be a motto for all we do: "This is my message to you: whatever you do, being a good human being is the most important"
    36K
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    E. John Wherry
    @EJohnWherry
    Mar 30, 2023
    I am so incredibly humbled an honored by this award. Thank you to @AACR and @CancerResearch for all the support and to all the amazing trainees and colleagues I've been fortunate to work with.
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    AACR
    @AACR
    Mar 30, 2023
    We congratulate @EJohnWherry, of @PennMedicine on being recognized with the 2023 AACR-CRI Lloyd J. Old Award in Cancer Immunology. Learn more: bit.ly/40qAhnB @CancerResearch
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    E. John Wherry
    @EJohnWherry
    Aug 23, 2021
    This is incorrect. Vaccinated people can get infected with measles. This does happen. They don't get (as) sick and they don't transmit. THAT is how a #vaccine works. eurosurveillance.org/content/10.280…
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    David Usharauli
    @3DiMMUNE
    Aug 22, 2021
    measles vaccinated person can go inside the room full of measles-infected people, kiss all of them and still remain protected against measles. This is a #vaccine that works.
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    E. John Wherry
    @EJohnWherry
    Jun 17, 2019
    Really excited! Our new paper on Tox as an epigenetic and transcriptional programmer of T cell exhaustion out today in Nature (rdcu.be/bG440). Beautiful work by Omar Khan. Unfortunately, the wrong Fig 3 was put in this advanced online version. Correct Fig 3 attached
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