Adaptyv Bio (@adaptyvbio) / X

Adaptyv Bio

213 posts

Adaptyv Bio

@adaptyvbio

You design proteins - we run the lab. We build an automated lab that enables anyone to become a protein designer.

Joined July 2021

Pinned
Adaptyv Bio
@adaptyvbio
Jan 22
The results of the Nipah Protein Design Competition are out! 🧬 1200 proteins experimentally validated (3x more than last year) 📈 99 novel binders against the target protein (a challenging tetramer with little prior work) 💪 26 single digit nM or better binders, with the
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Adaptyv Bio
@adaptyvbio
Jun 8
AI has solved software. Biology is the next frontier. We're hiring across every team at Adaptyv. We’ve built the best automated lab for protein designers to experimentally test their AI-designed proteins. Today, the most advanced protein design companies run their wet-lab work
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Adaptyv Bio
@adaptyvbio
Jun 8
Apply here: adaptyvbio.com/careers
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Adaptyv Bio
@adaptyvbio
Jun 2
Step 4: you know where 👀
Zeming Lin
@ebetica
Jun 2
How to design your own PD-1 binder in 4 easy steps: 1. Download the tutorial notebook from the ESM team 2. Get a @modal API key to scale it up 3. Scaling it up, O($1000) will get you a 96 well plate of minibinders with >50% success rates on typical targets 4. Test it in the lab!
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Adaptyv Bio reposted
Roshan Rao
@proteinrosh
Jun 2
We have fully open sourced our binder design protocol, which generates nanomolar affinity scFvs. The code here implements a faithful reproduction of the pipeline described in the paper, which is exactly what was used to produce our designs. Check it out here:
Thomas Hayes
@THayes427
Jun 2
Replying to @THayes427
We’re excited to share the full binder design protocol. Check it out here: github.com/Biohub/esm/blo…. The notebook includes support for @modal to easily scale up binder generation. Give it a try and let us know how it works! You can read more about ESMFold2, ESMC, ESM Atlas,
esm/cookbook/tutorials/binder_design.ipynb at main · Biohub/esm
From github.com
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Adaptyv Bio reposted
Bowen Jing
@bjing2016
Jun 1
Binder design has come of age thanks to generative models—but how can we access the wider array of dynamic, multistate protein functions, so elegantly employed by nature? @mihirbafna14 and I are excited to share SwitchCraft, a framework for designing such functions. (1/7)
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Adaptyv Bio
@adaptyvbio
May 13
What happens when you let frontier LLMs design proteins, and then synthesize and test them in a wet lab? We ran a protein design competition with @muni_bio where AI agents competed against humans to design molecules that bind TREM2, a key receptor linked to Alzheimer’s.
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Adaptyv Bio
@adaptyvbio
May 13
Replying to @adaptyvbio
Honest caveat: we measured binding, on one target, in one day, which is the easy half of a therapeutic. We'd go as far as to claim binding is roughly solved. Whether agent-grade design holds for developability, immunogenicity, PK/PD or in vivo potency, we don't know yet.
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Adaptyv Bio
@adaptyvbio
May 13
Everything's open. Designs and binding affinity data on @proteinbase, all open-source under ODC-BY. Blog: adaptyvbio.com/blog/agents-vs… Proteinbase collection: proteinbase.com/collections/ad…
adaptyvbio.com
Can LLMs design proteins?
After a busy few weeks of binding assays, we're ready to release the results from the muni × Adaptyv TREM2 hackathon. 16 teams designed binders against TREM2 in a single day in San Francisco: 10...
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Adaptyv Bio
@adaptyvbio
May 11
We've been saying it for a while, and @labriataphd makes the same case in his new article: binder design is having its AlphaFold moment. Several of our open competitions are cited as the main wet-lab evidence: BindCraft on EGFR, @cradlebio on the follow-up, and the Nipah
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Adaptyv Bio
@adaptyvbio
May 11
Check it out here:
The latest AI breakthroughs in structural biology: protein binder design and conformational state...
From nature.com
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Adaptyv Bio reposted
PeptAI
@peptai_
May 7
Replying to @peptai_
How the agent fleet is built and how it pays for tools autonomously. Each receptor has a dedicated agent with tiered memory of the full gate methodology, covering BioOS candidate sourcing, Lightfold computational analysis, and the @adaptyvbio API for wet lab handoff. Agents
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Adaptyv Bio
@adaptyvbio
May 6
Starting today, you can submit protein candidates from Benchling directly to the Adaptyv wet-lab. We're launching as part of @benchling's Direct Ordering Partners, alongside @TwistBioscience for DNA synthesis and @Ginkgo for antibody developability.
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Adaptyv Bio
@adaptyvbio
May 6
Replying to @adaptyvbio
Some of our customers already run this way, meaning a few designers with Benchling accounts and Adaptyv as the lab. As of today, test it on Adaptyv is one click away from where their work already lives.
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Adaptyv Bio
@adaptyvbio
May 6
In early access for all Benchling customers starting today. To set it up, get an Adaptyv API key by reaching out to us at [email protected] Blog: adaptyvbio.com/blog/benchling Benchling's full announcement: benchling.com/blog/one-click…
adaptyvbio.com
Test proteins with Adaptyv directly from Benchling
You can now submit protein candidates to the Adaptyv wet-lab directly from Benchling. We're launching as part of Benchling's Direct Ordering Partners, having integrated our Adaptyv API into Benchli...
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