Peter Fedichev (@fedichev) / X

Peter Fedichev

5,099 posts

Peter Fedichev

@fedichev

A physicist in drug discovery land. On a mission to significantly extend human lifespan | Founder of Gero.ai @hacking_aging) | WEF Tech Convergence group

Singapore

youtube.com/@fedichev

Born October 25

Joined April 2009

Pinned
Peter Fedichev
@fedichev
Apr 12
thank you, @EleanorSheekey for your questions and @agingdoc1 for spreading the link. Here lifespan.io/news/playing-t… and here biorxiv.org/content/10.110… are the popular and academic versions of the narrative discussed on the podcast. Friends, help please, as usual, spread the
Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM
@agingdoc1
Apr 11
How We Should Target Aging | Peter Fedichev Love what @EleanorSheekey is doing with @SheekeyScience. One of the sharpest geroscience #scicomm channels around, and @fedichev always brings the fire 🧪 youtube.com/watch?v=buEPyB…
Playing the Long Game Towards Radical Life Extension
From lifespan.io
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Peter Fedichev
@fedichev
Dec 30, 2023
What should we remember about the future as we head into the New Year? Especially given that in recent years, we've narrowly avoided a global, possibly even man-made, epidemic? The world teeters on the brink, engaged in a war with nuclear-armed participants, all under the shadow
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Peter Fedichev
@fedichev
Jul 24, 2025
As you know I'm obsessed with power laws in biology, which is a biological consequence of fundamental principles, like energy conservation from the first law of thermodynamics. Geoffrey West showed how highly optimized biological networks—think blood vessels or respiratory
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Peter Fedichev
@fedichev
Jul 7, 2025
BREAKING: Gero Signs Potential Multi-Billion-$ Deal to Fuel Our Mission to Stop Aging -- A few years ago, my son, aged five at the time, asked what happened to the dinosaurs. After learning their sad story, he told me he wanted to fly to the Moon and defend Earth from falling
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Peter Fedichev
@fedichev
Aug 29, 2023
Okay, let me run a provocation. In our information bubble related to the research and development of anti-aging drugs, it is customary to discuss the concept of longevity escape velocity (LEV). The discussion is often framed as if LEV is almost achieved. What could possibly go
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Peter Fedichev
@fedichev
Nov 22, 2023
Aging is so obviously bad, yet most (but not all) living creatures age. To make significant progress against aging, it’s crucial to understand why aging might be evolutionarily advantageous.The first glimpse of the answer I've got a while ago from Professor Robert Schmukler Rice,
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Peter Fedichev
@fedichev
Jul 27, 2025
When Isaac Asimov first published Foundation in the early 1950s, it was a revolution. Here was a vision of humanity sprawling across the stars, governed not by emperors or empires alone, but by mathematical inevitability — the grand science of psychohistory. It was the book that
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Peter Fedichev
@fedichev
Oct 2, 2023
Most doctors are taught and believe that the brain dies after about five or 10 minutes of oxygen deprivation. That is actually not true. The evidence comes from an expansive multi-year study led by Sam Parnia, an intensive care doctor and an associate professor in the department
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Peter Fedichev
@fedichev
Feb 25, 2024
It's been a while since I've posted here (there will be a new quite provocative preprint online in a few days). In the meanwhile, let's dive into something light. As you know, I have a fondness for history, especially where it intersects with science and the study of longevity.
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Peter Fedichev
@fedichev
Oct 28, 2023
Magic
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Peter Fedichev
@fedichev
Oct 29, 2023
It may sound strange, but beyond our "longevity" bubble people often ask: what are the reasons, scientifically, culturally, etc. for the reasons why people want to stop aging? My guess is that consciousness, once emerged, faced the vastness of universe and shortness of life.
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Peter Fedichev
@fedichev
Jun 23, 2025
Designing small molecules to hit protein targets is the holy grail of drug discovery, but it’s a beast of a problem. For years, I’ve been obsessed with finding a practical way to crack it. Coming from a physics background, my gut always leaned toward modeling—think docking +
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Peter Fedichev
@fedichev
Oct 8, 2025
We still don’t have a proper theory of aging. That’s remarkable, given how far biology has come. Despite centuries of speculation and decades of data, there is still no unified, quantitative framework that explains how and why living systems age—and how we might stop it. What
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Peter Fedichev
@fedichev
Jun 25, 2024
There’s another super-important piece of aging puzzle revealed in a recent paper: with a lot more observations, the mortality hazard of naked mole-rats failed to increase with age. One picture is worth a thousand words. As many of you know, “the naked mole-rat (Heterocephalus
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