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Patrick Hsu
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Patrick Hsu

@pdhsu
@ArcInstitute co-founder, @Stanford professor, @ThriveCapital investor | biology and ML research | 🇨🇦 prev @harvard @broadinstitute, Fast Grants
patrickhsu.com
Joined March 2009
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  • Pinned
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    Patrick Hsu
    @pdhsu
    Sep 25, 2025
    Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The
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    01:32
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    Patrick Hsu
    @pdhsu
    Jun 26, 2024
    What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
  • user avatar
    Patrick Hsu
    @pdhsu
    Aug 14
    curious how many more wordcel things can be adapted for shape rotators
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    FleetingBits
    @fleetingbits
    Aug 13
    i've started having claude turn my codebases into visual diagrams so i can discuss the codebases with claude more easily - the moving dots are data snippets that i can inspect
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    Patrick Hsu
    @pdhsu
    Aug 12
    Bridge editing is a technology for inserting, excising, or inverting any two pieces of DNA. Delighted to report in @Nature today a new paper with @hnisimasu on the mechanism of bridge RNAs and how these programmable gene editors cut themselves out of the genome!
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    Patrick Hsu
    @pdhsu
    Sep 25, 2025
    Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The
  • user avatar
    Patrick Hsu
    @pdhsu
    Aug 8
    hmm 🤔 they must mean DNA encoded libraries for producing terpenes and phenols :)
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    Breaking911
    @Breaking911
    Aug 7
    A 162-year-old bottle of Guinness has been recovered from a shipwreck, with scientists hoping DNA preserved inside the beer could help recreate the original 1864 recipe.
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    Patrick Hsu
    @pdhsu
    Aug 6
    👏 please use site specific integrases!
    user avatar
    News from Science
    @NewsfromScience
    Aug 6
    A gene therapy given to a 13-month-old boy has, years later, led to a tumor in his brain after the virus carrying the gene inserted part of it directly into his DNA, researchers report. The mass was safely removed, but his case appears to be the first time a gene therapy
    Boy’s brain tumor tied to gene therapy
Researchers report first cancer caused by virus widely used to deliver genes, but say risk is low

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