🧪➡️💊 Going from discovery ➡️ improved CV outcomes in RCTs is very very challenging
20+ once-promising CV targets, oral GP IIb/IIIa, CB1, PDE-3, niacin, Lp-PLA2, aliskiren, all failed or harmed in major CV outcome trials ❌📉
A validated mechanism ≠ a proven therapy ❤️🔬
