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Das Lab
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Das Lab

@RDasLab
Our lab seeks an agile and predictive understanding of how RNAs structurally code for information processing and replication in living systems.
Stanford, CA
daslab.stanford.edu
Joined April 2019
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    Das Lab
    @RDasLab
    Aug 8
    We and @eternagame are joining the quest to find a molecule that can sustainably replicate itself. Pilot results on first 1000 designs are posted, next up will be million-design-scale expts. Come design at eternagame.org/labs/14660266 by Aug 31, 2026! #RNAworld
    user avatar
    Eterna
    @eternagame
    Aug 7
    Our Replicase pilot results found that the catalytic activity and copyability of the 71-89 polymerase ribozyme can be improved! We have launched a new puzzle for finding a version that excels at both properties simultaneously. Comp methods are encouraged to submit designs!
    Puzzle interface displaying both the secondary and tertiary structure of the ribozyme
  • user avatar
    Das Lab
    @RDasLab
    Aug 6
    #RNA computational design groups around the world delivered! Congrats as well to @eternagame players who contributed the 240-nt pseudoknot targets -- and baseline RNA sequences for #AI eval. Experiments are underway at @StanfordBiochem @HHMI Janelia Research Campus.
    user avatar
    Eterna
    @eternagame
    Aug 6
    Major props @DidiKieran @jgkoob @lemerleau @IIMCB_Poland @FrankRHutter @AF_Panescu @chaitjo @rishabh16_ for generating 600,000 sequences to fold into 1000 synthetic pseudoknots! The wet lab results will help these researchers improve their computational methods for RNA design.
  • user avatar
    Das Lab
    @RDasLab
    Jul 24
    RNA flexible? Maybe we can model that. First blind test of RNA 3D *ensemble* prediction — ligand-free SAMURI ribozyme (displayed on a group II intron scaffold) -- #MD and #deeplearning methods welcome, deadline Aug 22, 2026: predictioncenter.org/casp17/target.…
    Image
  • user avatar
    Das Lab
    @RDasLab
    Jul 14
    Pseudoknots, AI, and preview of Eterna's first RNA replicase results at EternaCon 12, virtual on Sunday July 26, 2026! Preregister for free at: eternagame.org/eternacon/2026
    Image
  • user avatar
    Das Lab
    @RDasLab
    Jul 9
    Can humans+AI get 1M #cryoEM-able #RNA structures? Phase 1: humans design 1000 pseudoknot structures @eternagame by Jul 19. Phase 2: AIs design 1000 sequences for each by Jul 31. Come join! Latest phase of the OpenKnot challenge eternagame.org/challenges/118…
    user avatar
    Eterna
    @eternagame
    Jul 7
    Eterna's newest puzzle challenges players to design 240-base RNA strands that will fold into compact pseudoknots. The puzzle provides a metric for counting the number of pairs that cross to form large, synthetic pseudoknots. Check out the puzzle at eternagame.org/labs/14333719
    ZG_25 by Father_Z

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