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Lowe Lab
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Lowe Lab
@LoweLabMSKCC
Our lab focuses on genetic changes in cancer and how they contribute to tumorigenesis in the hope of finding therapeutic targets. Tweets from Scott signed -SWL.
New York, NY
mskcc.org/research/ski/lโ€ฆ
Joined October 2019
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  • user avatar
    Lowe Lab
    @LoweLabMSKCC
    Aug 17, 2022
    Out in @Nature today, we report that #p53 loss unleashes an ordered & selective pattern of cancer #GenomeEvolution: nature.com/articles/s4158โ€ฆ. 1/n
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    Ordered and deterministic cancer genome evolution after p53 loss
    From nature.com
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    Lowe Lab
    @LoweLabMSKCC
    Feb 3, 2021
    Out in @Nature today, our latest work shows how tissue injury and Kras mutation cooperate to induce an epigenetic program that initiates pancreatic tumorigenesis. nature.com/articles/s4158โ€ฆ (1/3)
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    Lowe Lab
    @LoweLabMSKCC
    Jun 17, 2020
    Out in @Nature today, our latest work provides a proof of concept for the utility of #CART cells as #senolytics. This study was an exciting collaboration with the #SadelainLab... (1/3) nature.com/articles/s4158โ€ฆ
  • user avatar
    Lowe Lab
    @LoweLabMSKCC
    Jun 28, 2022
    My 2nd Spanish postdoc @AmaiaLujambio is an inspiring scientist & friend. With @KrizhanovskyLab, she revealed key links b/w senescence & tumorigenesis. She was a point person in our transition @CSHL โžก๏ธ @MSKCancerCenter. So proud of her success at @IcahnMountSinai! โ€“SWL #LoweLab25
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    Lowe Lab
    @LoweLabMSKCC
    Jun 21, 2022
    To mark 25 years (!!) since my first faculty appointment, I will be highlighting some of the fantastic Lowe lab trainees over the years, from its origins @CSHL to evolution @MSKCancerCenter. These are the people that made the Lowe lab what it is today. Stay tuned! โ€“SWL #LoweLab25
  • user avatar
    Lowe Lab
    @LoweLabMSKCC
    Aug 23, 2022
    New Preprint! Led by #DynamicDuo @BarrigaFM & @KTsanov, this study set out to understand how somatic copy number alterations (CNAs) promote cancer. CNAs are prevalent across cancer types & correlate w/ clinical outcomes but remain difficult to study. 1/n
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    biorxiv.org
    Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression
    Somatic chromosomal deletions are prevalent in cancer, yet their functional contributions remain ill-defined. Among the most prominent of these events are deletions of chromosome 9p21.3, which...
  • user avatar
    Lowe Lab
    @LoweLabMSKCC
    Jun 22, 2022
    My 2nd postdoc Marisol Soengas @msmelanoma helped establish a culture of drive & excellence in the lab @CSHL. After a successful tenure @UMich, she returned home to @CNIOStopCancer, where she is Head/Melanoma Group & VP @ASEICAnews. Check out her inspiring work! โ€“SWL #LoweLab25
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    Lowe Lab
    @LoweLabMSKCC
    Jan 4, 2024
    First publication of 2024! Now out in @NatureCancer, the final (and substantially expanded) version of our work that develops a new suite of mouse models to study #MetastaticGastricCancer of customizable #Genotypes and #HostBackgrounds: nature.com/articles/s4301โ€ฆ.
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    Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
    From nature.com
    28K028K
  • user avatar
    Lowe Lab
    @LoweLabMSKCC
    Sep 19, 2023
    What an incredible Reunion! It was wonderful to see all former lab members who traveled to NYC from all over the world & to experience the joy that we all shared in getting together. THANK YOU & stay in touch! #LoweLab25
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    21K021K
  • user avatar
    Lowe Lab
    @LoweLabMSKCC
    Oct 21, 2019
    Congratulations to Dr. Lowe for his recent election to the @theNAMedicine!
    user avatar
    Memorial Sloan Kettering Cancer Center
    @MSKCancerCenter
    Oct 21, 2019
    Join us as we congratulate our own Dr. Scott W. Lowe, who was just elected to the @theNAMedicine! Want to know more about Dr. Lowe's award-winning research? Follow us behind the scenes in his lab. @LoweLabMSKCC #NAMmtg bit.ly/2W4CrIX
  • user avatar
    Lowe Lab
    @LoweLabMSKCC
    Jan 26, 2022
    Out in @PNASNews today, we report new flexible mouse models of #OvarianCancer, and use them to gain insights into the role of #Senescence in chemo- & immunotherapy responses: pnas.org/content/119/5/โ€ฆ.
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    pnas.org
    Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian...
    High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to the limited effectiveness of existing chemo- and immunotherapi...
  • user avatar
    Lowe Lab
    @LoweLabMSKCC
    Nov 7, 2022
    Now out in @NatureCancer, an updated version of our study developing the #MACHETE strategy for modeling large genomic deletions and using it to uncover a key role for type I #IFN deletions in tumor #ImmuneEvasion & #Metastasis: nature.com/articles/s4301โ€ฆ (1/3)
    user avatar
    Lowe Lab
    @LoweLabMSKCC
    Aug 23, 2022
    New Preprint! Led by #DynamicDuo @BarrigaFM & @KTsanov, this study set out to understand how somatic copy number alterations (CNAs) promote cancer. CNAs are prevalent across cancer types & correlate w/ clinical outcomes but remain difficult to study. 1/n biorxiv.org/content/10.110โ€ฆ
  • user avatar
    Lowe Lab
    @LoweLabMSKCC
    Aug 30, 2022
    Congratulations to postdoc @KTsanov on receiving the @NIH K99/R00 Pathway to Independence Award!! ๐Ÿ‘๐ŸŽ‰๐Ÿš€
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    Lowe Lab
    @LoweLabMSKCC
    Jun 21, 2021
    First major Lowe lab event in 18 months. It was great to see everyone together and having fun. We are back!
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