Reflecting on 2024: a category sweep of the Nobels, AI enabled clinical readouts, and the first trillion dollar pharma in sight.
We stand on the shoulders of giants. Looking to 2025: This is just the beginning. Make no small plans.
a few years ago we office’d @joshim5@jackdent and the early @chaidiscovery team in our noho hq as they traversed the 0 to 1 of newco genesis. alongside thrive and OAI we led the first financing into the company
today, as CHAI sets the bar for generative molecular design -
Today we’re launching @chaidiscovery, led by @joshim5 & his polymathic world class cofounders. We’re also open sourcing Chai-1: a state of the art frontier model for biomolecular interactions. @_DimensionCap has co-led the founding round alongside Thrive & OpenAI
enjoyed chatting with @SabrinaHalper in the lab (!) a few weeks back
rarely do i get to cover whale lifespans, @newlimit, spacefaring human speciation events, & ai therapeutic design in one place
"Aging is the process of a complex system slowly falling into its chaotic disequilibrium. And it's not like evolution necessarily even set a lifespan for us. It is merely the result of, once the system has been established, how long its intrinsic property stayed ordered before
I'm delighted to announce a new collaboration between @chaidiscovery & @Novartis.
It's been a pleasure working together over the past year, and we're excited to scale our collaboration to support broader deployment of Chai-3 across multiple therapeutic programs.
this is our most dynamic summer yet @newlimit
- 3X data efficiency for reprogramming AI from lineage generalization
- >100X manufacturing scale for our lead therapeutic asset
- +4 leads that restore function in old hepatocytes, +5 payloads in endothelium
& lots more in our blog
For large pharma companies serious about integrating ML throughout their organizations, I believe they'll need infrastructure like what @tamarindbio has created.
With so many open and closed source solutions, a constantly changing model backdrop, pipelines that need
We’re proud to share that @tamarindbio has been selected to build, host, and operate the inference infrastructure layer for TuneLab2.0, the next evolution of the platform. @EliLillyandCo TuneLab is a first-of-its-kind, collaborative AI/ML drug discovery platform, bringing models
every year @newlimit, we host friends at the lab & share our progress
for 2026, we announced:
- 2X increase in discovery rates with AI systems
- new program for endothelial cells
- 0 -> 1 medicines headed to the clinic
- accelerating recovery from alcohol
some highlights --
Congrats to Deniz, Sherry and @tamarindbio team on the partnership with Lilly! Excited to announce that Lilly's TuneLab model initiative will be solely powered by Tamarind's platform.
There are more high performance open and closed-source bio ML models now than ever. Tamarind
We’re proud to share that @tamarindbio has been selected to build, host, and operate the inference infrastructure layer for TuneLab2.0, the next evolution of the platform. @EliLillyandCo TuneLab is a first-of-its-kind, collaborative AI/ML drug discovery platform, bringing models
2 years ago Chai was a small team led by @joshim5 & @jackdent working out of the Dimension offices
today they are leading the charge to reinvigorate western pharma and biotech. Lilly and Pfizer are partners. the majority of pharma queuing up..
the rate of progress: staggering
Today we’re launching @chaidiscovery, led by @joshim5 & his polymathic world class cofounders. We’re also open sourcing Chai-1: a state of the art frontier model for biomolecular interactions. @_DimensionCap has co-led the founding round alongside Thrive & OpenAI
Today we are announcing our collaboration with Pfizer to put Chai's frontier AI—including our latest model, Chai-3—directly into the hands of one of the world's leading pharmaceutical teams.
It's been amazing to watch @joshim5, @jackdent, and team work at speed.
This is the wrong time to be a goalpost mover or a chronic under-estimator of ML velocity, and my team at @_DimensionCap would agree.
Chai is speed-running what I thought would take years and years. I'm
Today we are announcing our collaboration with Pfizer to put Chai's frontier AI—including our latest model, Chai-3—directly into the hands of one of the world's leading pharmaceutical teams.
Today we are announcing our collaboration with Pfizer to put Chai's frontier AI—including our latest model, Chai-3—directly into the hands of one of the world's leading pharmaceutical teams.
New Limit just raised $435 million. This is, in part, because they've had a massive breakthrough on reversing the age of the liver with their new brand of genetic reprogramming drugs.
For the first time, NewLimit's co-founder and president Jacob Kimmel details the company's