Joshua Meier (@joshim5) / X

Joshua Meier

615 posts

Joshua Meier

@joshim5

Co-Founder at Chai Discovery

San Francisco

Joined March 2009

Pinned
Joshua Meier
@joshim5
Jul 14
Tomorrow's medicines should be designed with the precision and scale of modern engineering. I'm thrilled that @chaidiscovery has raised a $400M Series C at a $3.8B valuation from @IndexVentures @kleinerperkins @sequoia @_DimensionCap to accelerate progress towards that goal.
Chai Discovery
@chaidiscovery
Jul 14
We’ve raised $400M at a $3.8B valuation to further advance AI-driven molecular design. The round was led by @IndexVentures, alongside @kleinerperkins, @sequoia, @_DimensionCap, and others.
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Joshua Meier
@joshim5
Sep 9, 2024
We’re excited to introduce @chaidiscovery and release Chai-1, a foundation model for molecular structure prediction that performs at the state-of-the-art across a variety of drug discovery tasks We're releasing inference code, weights & a web interface: chaidiscovery.com/blog/introduct…
Joshua Meier
@joshim5
Aug 6, 2025
Proud to announce @ChaiDiscovery has raised a $70M Series A from @MenloVentures & Anthology Fund (@AnthropicAI), @ThriveCapital, @OpenAI + others. 🧬 Chai is an applied AI lab building frontier tools for molecular design. This funding will power our new models, coming soon👇
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Joshua Meier
@joshim5
Jan 10, 2023
📢 Our new #manuscript shows how zero-shot Generative AI can create de novo antibodies from scratch. 🏅Hundreds of antibodies are created zero-shot and validated in the wet-lab for the first time ever. Paper: biorxiv.org/content/10.110… Data: github.com/AbSciBio/unloc…
Joshua Meier
@joshim5
Jul 12, 2022
Neural networks can now be built from proteins! Can we use protein-based neural networks to design new proteins? 🤯 Self-replicating and self-improving biology sounds familiar…🤔
Zibo Chen
@ZiboChen
Jul 12, 2022
Can proteins perform neural network computation? Together with James Linton, @RonZhu2015, and @ElowitzLab, we had a lot of fun creating the "perceptein" -- a protein circuit that performs winner-take-all neural network computation in mammalian cells: biorxiv.org/content/10.110… (1/4)
Joshua Meier
@joshim5
Aug 18, 2022
🚨We are releasing a new #manuscript highlighting how our AI-based drug discovery platform can rapidly optimize parameters critical to drug development. ‍🔬Wet-lab data shows that our AI-generated protein drugs exhibit their designed qualities. Paper: biorxiv.org/content/10.110…
Joshua Meier
@joshim5
Jun 19, 2022
Protein folding from single sequences is enabled by replacing MSAs with protein language models! Amazing how rapidly this field has evolved since we started with LM-based "contact prediction" in 2019 🚀
Jian Peng
@_jianpeng
Jun 19, 2022
Protein structure can be predicted from a single sequence alone with high accuracy. @HelixonBio team have developed OmegaFold, achieving performance similar to RF and AF2's MSA versions. Only a single sequence is given as input. 1/5
Joshua Meier
@joshim5
Jun 30, 2025
I've been working on variants of this problem for my entire career, and have only dreamed of designing molecules on the computer with success rates this high. Proud of @chaidiscovery for pulling this off, and doing it with the speed, rigor and grace that was only imaginable ✨
Chai Discovery
@chaidiscovery
Jun 30, 2025
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
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Joshua Meier
@joshim5
Jul 7, 2025
Chai-2 is now up on BioRxiv: biorxiv.org/content/10.110…
Biology+AI Daily
@BiologyAIDaily
Jul 7, 2025
Zero-shot antibody design in a 24-well plate @chaidiscovery 1. Researchers have introduced Chai-2, a multimodal generative model that marks a significant leap in de novo antibody and miniprotein design. This platform achieves an impressive 16% hit rate in de novo antibody
Joshua Meier
@joshim5
Sep 2, 2020
Excited to share an update to our work on evolutionary-scale modeling (ESM)! Over the past year, we rewrote our paper with better pretraining and downstream models, leading to state-of-the-art results across multiple benchmarks. (1/8) biorxiv.org/content/10.110…
Joshua Meier
@joshim5
Dec 5, 2024
Folding proteins on Modal with @chaidiscovery Chai-1. Comprehensive guide with working code samples from the @modal_labs team.
Fold proteins with Chai-1
From modal.com
Joshua Meier
@joshim5
Nov 27, 2024
I'm excited to share that we're making this technology available for broad commercial use, starting today. It's been amazing to witness the rapid adoption of Chai-1. We can't wait to see all the ways it will accelerate drug discovery.
Chai Discovery
@chaidiscovery
Nov 27, 2024
Chai-1 has always been available for commercial use via our server. Today, we're also making Chai-1(r) code and weights available under an Apache 2.0 license, which permits broad commercial use. github.com/chaidiscovery/…
Joshua Meier
@joshim5
Aug 20, 2025
🧬 Dr. Mikael Dolsten is joining the @chaidiscovery board! In 15 years as @pfizer's Chief Scientific Officer he: ⚛️ Progressed 150 molecules to clinical trials 💊 Delivered 36 approved medicines, from vaccines to cancer therapies
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Joshua Meier
@joshim5
Sep 9, 2024
Replying to @joshim5
We are releasing Chai-1 via a web interface for free, including for commercial applications such as drug discovery. We are also releasing the code for Chai-1 for non-commercial use as a software library. Web interface: lab.chaidiscovery.com Code: github.com/chaidiscovery/…
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