Origin (@origin

Origin

18 posts

Origin

@origin_bio

AI for safer cell and gene therapies

San Francisco, California

origin.bio

Joined September 2025

Following

1,280

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Origin
@origin_bio
Feb 4
Check out our YC launch!
Y Combinator
@ycombinator
Feb 4
Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer. Their model designs DNA switches & dials to program precise gene expression patterns in disease cells. Congrats on the launch @YashRathod_75 and @malhar317! ycombinator.com/launches/PMG-o…
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Origin reposted
Yash Rathod
@YashRathod_75
Mar 13
Today, we're excited to release 10,000 fully AI-designed enhancer sequences for the research community. Axis was prompted to design sequences with targeted activity in one of three widely used cell-lines. AI allows us to explore a vast design space, going beyond the natural
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Origin reposted
Viraj Doshi
@viraj9451
Mar 5
Muon can accelerate LLM training, but does that benefit transfer to regulatory DNA sequence modeling with its different data distribution? 🧬 Our results show that Muon with independent weight decay (MuonW) hits our validation perplexity target in ~37% fewer FLOPs than the best
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Origin reposted
malhar
@malhar317
Feb 21
It was an honor to meet PM @narendramodi and discuss the potential impact of the work we are doing at @origin_bio
Narendra Modi
@narendramodi
Feb 20
Interacted with CEOs of AI and deeptech StartUps at Seva Teerth. They are doing commendable work across sectors such as healthcare, agriculture, space, social enterprise and more. We discussed how to leverage the potential of AI in furthering the welfare of humanity.
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Origin reposted
malhar
@malhar317
Feb 5
Cell and gene therapies have the potential to offer a much higher quality of life to patients. Getting transcriptional control right is going to unlock a whole new class of them. Happy to share a small preview into Axis’ ability to design novel regulatory DNA sequences. It’s so
00:53
Y Combinator
@ycombinator
Feb 4
Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer. Their model designs DNA switches & dials to program precise gene expression patterns in disease cells. Congrats on the launch @YashRathod_75 and @malhar317! ycombinator.com/launches/PMG-o…
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Origin reposted
Yash Rathod
@YashRathod_75
Feb 4
We're still in the early days of durable and long lasting drugs based on transcriptional control - similar to where mRNA medicines were many years ago! With AI designed regulatory DNA and millions of sequences we're lab testing, we aim to precisely program gene expression
Y Combinator
@ycombinator
Feb 4
Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer. Their model designs DNA switches & dials to program precise gene expression patterns in disease cells. Congrats on the launch @YashRathod_75 and @malhar317! ycombinator.com/launches/PMG-o…
00:00
2.7K
Origin reposted
Y Combinator
@ycombinator
Feb 4
Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer. Their model designs DNA switches & dials to program precise gene expression patterns in disease cells. Congrats on the launch @YashRathod_75 and @malhar317! ycombinator.com/launches/PMG-o…
00:00
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Origin
@origin_bio
Oct 11, 2025
Interested in knowing more about how we beat Google DeepMind? We shared some insights on @tbpn
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Origin
@origin_bio
Oct 11, 2025
Read more about Axis here:
Introducing Axis — Origin
From origin.bio
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Origin
@origin_bio
Oct 11, 2025
On TBPN live, our co-founder and CEO shares more on how we plan to use Axis to develop new age gene therapies👇
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Origin
@origin_bio
Oct 11, 2025
Read more about Axis in our blog here:
Introducing Axis — Origin
From origin.bio
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Origin reposted
Yash Rathod
@YashRathod_75
Oct 8, 2025
Going on TBPN at 1:45 pm PT to launch @origin_bio and our model, Axis. Axis is the first model that generates regulatory DNA sequences and predicts its function. Axis already outperforms DeepMind's AlphaGenome on various benchmarks!
TBPN
@tbpn
Oct 8, 2025
Morning. On today’s show: – @karimatiyeh (Ramp) – @alexkshieh (The Antifraud Co) – @dteare (1Password) – @gilbert & @djrosent (Acquired) – @sergiynest (Quilter) – @JLopas (Base Power Co) – @ryanjdaniels (Crosby) – @zganieany (MeritFirst) – @YashRathod_75 (Origin) See you there.
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Origin
@origin_bio
Oct 8, 2025
Introducing Axis: the first AI model that generates regulatory DNA elements and predicts their function. Gene therapies suffer from poor efficacy, toxicity & specificity. Models like Axis can help overcome such risks. Axis beats Google DeepMind's AlphaGenome at predicting
GIF
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Origin
@origin_bio
Oct 8, 2025
Replying to @origin_bio
Natural genomes capture only a fraction of possible sequence designs permitted by underlying rules. Models like Axis explore this design space and can generate regulatory sequences that encode circuit-like logic, enabling cell type and state-specific activity.
GIF
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Origin
@origin_bio
Oct 8, 2025
We’re excited to take the model into the lab and open up public access soon! To get early access to the model, please fill out the form here: tinyurl.com/origin-axis-ac… If you enjoyed this thread and want to learn more about Axis, read our blog post: origin.bio/introducing-ax…
docs.google.com
Axis Model Access
We are interested in sharing access to the model via a free API to academic labs in order to get feedback. If you belong to a lab and are interested in either the wet-lab testing or trying out the...
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